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Morbid Risk Among First-Degree Relatives Approximates 50% by 90 Years of Age

Richard C. Mohs, PhD; John C. S. Breitner, MD; Jeremy M. Silverman, PhD; Kenneth L. Davis, MD

Arch Gen Psychiatry. 1987;44(5):405-408.

Abstract
• The morbid risk of Alzheimer's disease was studied in first-degree relatives of 50 patients who met contemporary clinical research diagnostic criteria and 45 matched controls. Relatives of patients showed a 46% cumulative incidence of probable Alzheimer's disease by 86 years of age. The risk, which was four times the control value, is consistent with other recent reports using similar, modern methods. Although not conclusive, the data suggest the operation of a relatively common, dominant autosomal gene for Alzheimer's disease, the expression of which is delayed until late old age but is largely complete by 90 years of age.

Author Affiliations
From the Psychiatry Service, Veterans Administration Medical Center, Bronx, NY (Drs Mohs, Breitner, Silverman, and Davis) and Pharmacology (Dr Davis), Mount Sinai School of Medicine, New York.

Footnotes
Accepted for publication Feb 23, 1987.

Reprint requests to Psychiatry Service (116A), Bronx Veterans Administration Medical Center, Bronx, NY 10468 (Dr Mohs).

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