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The Resting State Reconsidered

Craig N, Karson, MD; Richard Coppola, DSc; John M. Morihisa, MD; Daniel R. Weinberger, MD

Arch Gen Psychiatry. 1987;44(6):514-517.

Abstract
• Several topographic mapping studies of electroencephalographic (EEG) power spectra have reported increased slow (delta) activity in the frontal regions of schizophrenic patients. Using supraorbital and lateral canthus electrodes to detect eye movement, we deleted EEG epochs during eye movement in 15 medication-free patients with schizophrenia and in 13 normal control subjects. Power spectral analysis of the 28-channel EEG demonstrated a diffuse mild increase in delta activity in schizophrenic patients compared with normal control subjects but no tendency for frontal localization of this slow activity. There were no differences between schizophrenic patients and normal control subjects in other frequency bands. These results, which replicate earlier findings of increased delta activity in schizophrenia, emphasize the importance of excluding the slow activity due to eye movement in the comparisons of summed EEG spectra. This emphasis can best be ensured by equating the summed spectra from extraocular movement channels of experimental and control groups.

Author Affiliations
From the Clinical Brain Disorders Branch, National Institute of Mental Health, Washington, DC, and St Elizabeth's Hospital, Washington, DC (Drs Karson, Coppola, and Weinberger); and Washington (DC) Veterans Administration Medical Center (Dr Morihisa).

Footnotes
Accepted for publication Dec 30, 1986.

Reprint requests to St Elizabeth's Hospital, WAW Building, 2700 Martin Luther King Jr Blvd, Washington, DC 20032 (Dr Karson).

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