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Two-Year Outcome

Stephen R. Marder, MD; Theodore Van Putten, MD; Jim Mintz, PhD; Malca Lebell, PhD; Joanne McKenzie, RN; Philip R. A. May, MD

Arch Gen Psychiatry. 1987;44(6):518-521.

Abstract
• We evaluated the effectiveness and the side effects of what we defined as low (5-mg) and conventional (25-mg) doses of fluphenazine decanoate administered every two weeks in a double-blind comparison. Subjects were 66 patients who fulfilled DSM-III criteria for schizophrenic disorder. Evaluation of the survival with each dose revealed no significant difference at one year, but significantly better survival was seen with the 25-mg dose (64%) than the 5-mg dose (31%) at two years. There was no significant difference in survival when the clinician was permitted to make a dosage adjustment up to 10 mg in the lowdose group and 50 mg in the higher-dose group when the patient demonstrated evidence of a symptomatic exacerbation. Patients assigned to the higher dose appeared to feel more uncomfortable during the early months of the study, as indicated by significantly higher scores on subscales of the Hopkins Symptom Checklist-90R and higher side effect scores for retardation and akathisia. Implications for clinical practice are discussed.

Author Affiliations
From the West Los Angeles Veterans Administration Medical Center, Brentwood Division (Drs Marder, Van Putten, Mintz, Lebell, and May, and Ms McKenzie), and the School of Medicine, UCLA (Drs Marder, Van Putten, Mintz, and May).

Footnotes
Accepted for publication March 3, 1986.

Reprint requests to West Los Angeles Veterans Administration Medical Center, Brentwood Division, 11301 Wilshire Blvd, Los Angeles, CA 90073 (Dr Marder).

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