 |
|
An Efficacy Study of Isocarboxazid and Placebo in Depression, and Its Relationship to Depressive Nosology
Jonathan R. T. Davidson, MD;
Earl L. Giller, MD, PhD;
Sidney Zisook, MD;
John E. Overall, PhD
Arch Gen Psychiatry. 1988;45(2):120-127.
Abstract
| |
• Isocarboxazid and placebo were evaluated in 130 anxious depressives. Drug was superior to placebo on depression, anxiety, interpersonal sensitivity, and global measures, and on symptoms of hostility, anxiety, obsessiveness, and psychological-cognitive components of depression. There were no significant differences between treatment effects on psychomotor and typical vegetative symptoms. Isocarboxazid was more effective than placebo in major, but not in minor, depression. It was significantly more effective in depression classified as endogenous depression or melancholia by various diagnostic criteria. Drug was more effective than placebo in atypical depression with vegetative reversal and in Brief Psychiatric Rating Scale (BPRS)—derived profiles of anxious and hostile depression; there were no drug-placebo differences in atypical depression without vegetative reversal, or in BPRS retarded and agitated/excited depression. Interpersonal sensitivity emerged as an important drug-responsive dimension.
Author Affiliations
From the Departments of Psychiatry, Veterans Administration Medical Center and Duke University Medical Center, Durham, NC (Dr Davidson); Departments of Psychiatry, West Haven (Conn) Veterans Administration Medical Center and Yale University, New Haven, Conn (Dr Giller); Department of Psychiatry, University of California at San Diego (Dr Zisook); and Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston (Dr Overall).
Footnotes
Accepted for publication April 9, 1987.
Reprint requests to the Department of Psychiatry, Veterans Administration Medical Center, Fulton Street, Durham, NC 27705 (Dr Davidson).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Differential Stimulant Response on Attention in Children With Comorbid Anxiety and Oppositional Defiant Disorder
Goez et al.
J Child Neurol 2007;22:538-542.
ABSTRACT
Depression With Atypical Features in the National Comorbidity Survey: Classification, Description, and Consequences
Matza et al.
Arch Gen Psychiatry 2003;60:817-826.
ABSTRACT
| FULL TEXT
Placebo Response in Studies of Major Depression: Variable, Substantial, and Growing
Walsh et al.
JAMA 2002;287:1840-1847.
ABSTRACT
| FULL TEXT
Treatments of Depression and the Functional Capacity to Work
Mintz et al.
Arch Gen Psychiatry 1992;49:761-768.
ABSTRACT
The Definition and Operational Criteria for Treatment Outcome of Major Depressive Disorder: A Review of the Current Research Literature
Prien et al.
Arch Gen Psychiatry 1991;48:796-800.
ABSTRACT
Phenelzine and Imipramine in Mood Reactive Depressives: Further Delineation of the Syndrome of Atypical Depression
Quitkin et al.
Arch Gen Psychiatry 1989;46:787-793.
ABSTRACT
Antidepressants: Their efficacy and place in therapy
Paykel
J Psychopharmacol 1988;2:105-118.
ABSTRACT
|
