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A Replication in Depressed Patients and Controls

Alec Roy, MB; Sally Guthrie, PharmD; Farouk Karoum, PhD; David Pickar, MD; Markku Linnoila, MD, PhD

Arch Gen Psychiatry. 1988;45(2):158-161.

Abstract
• We examined the intercorrelations among urinary outputs of norepinephrine (NE) and its three major metabolites in unipolar depressed patients (n = 28) and normal controls (n = 24). Among the depressed patients, levels of NE correlated with normetanephrine (NM), 3-methoxy-4-hydroxyphenylglycol (MHPG), and vanillylmandelic acid (VMA), and VMA correlated with NM and MHPG. In the total group of depressed and control subjects (n = 52), the sum of NE and its major metabolites correlated with urinary outputs of NE, NM, MHPG, and VMA. These highly significant correlations among urinary outputs of NE and its major metabolites replicate a previous report of strong correlations among these same four urinary substances in a smaller group of depressed patients.

Author Affiliations
From the Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism (Drs Roy, Guthrie, and Linnoila); and the Adult Psychobiology (Dr Karoum) and Clinical Neuroscience (Dr Pickar) Branches, National Institute of Mental Health, Bethesda, Md.

Footnotes
Accepted for publication July 21, 1987.

Reprint requests to National Institutes of Health, Bldg 10, R3B-19, 9000 Rockville Pike, Bethesda, MD 20892 (Dr Roy).

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