Comparison of Patients With and Without Poststroke Major Depression Matched for Size and Location of Lesion

doi:10.1001/archpsyc.1988.01800270061007

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Vol. 45 No. 3, March 1988

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Comparison of Patients With and Without Poststroke Major Depression Matched for Size and Location of Lesion

Sergio E. Starkstein, MD; Robert G. Robinson, MD; Thomas R. Price, MD

Arch Gen Psychiatry. 1988;45(3):247-252.

Abstract

• Patients who developed major depression within two yearsfollowing stroke (n = 13) were compared with patients who didnot become depressed in the same period (n = 13) but who didhave a similar size and location of lesion as in the depressedgroup. Although the depressed patients were not significantlydifferent from the nondepressed patients in background characteristics,history of depressive disorder, neurological impairment, orsocial functioning, the depressed group had greater cognitiveimpairment as measured by Mini-Mental State score. In addition,the depressed group had significantly larger lateral and thirdventricular to brain ratios than nondepressed patients on computedtomographic scan analysis. The results suggest that poststrokedepression itself may produce an intellectual impairment; subcorticalatrophy, which likely preceded the stroke lesion, may producea vulnerability for depression following stroke.

Author Affiliations

From the Departments of Psychiatry and Behavioral Sciences (Drs Starkstein and Robinson) and Neurosciences (Dr Robinson), The Johns Hopkins University School of Medicine, and the Department of Neurology, University of Maryland School of Medicine (Dr Price), Baltimore.

Footnotes

Accepted for publication Sept 30, 1987.

Reprint requests to Department of Psychiatry, Meyer 4-119, TheJohns Hopkins University School of Medicine, Baltimore, MD 21205(Dr Starkstein).

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