 |
|
Pathological GamblingA Psychobiological Study
Alec Roy, MB;
Bryon Adinoff, MD;
Laurie Roehrich;
Danuta Lamparski, PhD;
Robert Custer, MD;
Valerie Lorenz, PhD;
Maria Barbaccia, MD;
Alessandro Guidotti, MD;
Erminio Costa, MD;
Markku Linnoila, MD, PhD
Arch Gen Psychiatry. 1988;45(4):369-373.
Abstract
• We investigated psychobiological substrates of pathological gambling by measuring levels of norepinephrine, monoamine metabolites, and peptides in cerebrospinal fluid, plasma, and urine. Pathological gamblers had a significantly higher centrally produced fraction of cerebrospinal fluid levels of 3-methoxy-4-hydroxyphenylglycol as well as significantly greater urinary outputs of norepinephrine than controls. These results suggest that pathological gamblers may have a functional disturbance of the noradrenergic system. This system has been postulated to underlie sensation-seeking behaviors, aspects of which are thought to be abnormal among pathological gamblers.
Author Affiliations
From the Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md (Drs Roy, Adinoff, Lamparski, and Linnoila and Ms Roehrich); Taylor Manor Hospital, Ellicott City, Md (Dr Custer); the National Center for Pathological Gambling, Baltimore (Dr Lorenz); and Fidia Georgetown Institute for the Neurosciences, Washington, DC (Drs Barbaccia, Costa, and Guidotti).
Footnotes
Accepted for publication Oct 6, 1987.
Reprint requests to the National Institute on Alcohol Abuse and Alcoholism, Bldg 10, Room 3B19, 9000 Rockville Pike, Bethesda, Md 20892 (Dr Roy).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Disulfiram, an Option for the Treatment of Pathological Gambling?
Mutschler et al.
Alcohol Alcohol 2010;45:214-216.
ABSTRACT
| FULL TEXT
Decision-making during gambling: an integration of cognitive and psychobiological approaches
Clark
Phil Trans R Soc B 2010;365:319-330.
ABSTRACT
| FULL TEXT
The neurobiology of pathological gambling and drug addiction: an overview and new findings
Potenza
Phil Trans R Soc B 2008;363:3181-3189.
ABSTRACT
| FULL TEXT
Personality and Problem Gambling: A Prospective Study of a Birth Cohort of Young Adults
Slutske et al.
Arch Gen Psychiatry 2005;62:769-775.
ABSTRACT
| FULL TEXT
Common Genetic Vulnerability for Pathological Gambling and Alcohol Dependence in Men
Slutske et al.
Arch Gen Psychiatry 2000;57:666-673.
ABSTRACT
| FULL TEXT
Pathological gambling
Blume
BMJ 1995;311:522-523.
FULL TEXT
Marked Reduction in Indexes of Dopamine Metabolism Among Patients With Depression Who Attempt Suicide
Roy et al.
Arch Gen Psychiatry 1992;49:447-450.
ABSTRACT
Extraversion in Pathological Gamblers: Correlates With Indexes of Noradrenergic Function
Roy et al.
Arch Gen Psychiatry 1989;46:679-681.
ABSTRACT
|
