 |
|
Secondary Depression in Panic Disorder and AgoraphobiaI. Frequency, Severity, and Response to Treatment
Ira M. Lesser, MD;
Robert T. Rubin, MD, PhD;
John C. Pecknold, MD;
Arthur Rifkin, MD;
Richard P. Swinson, MD;
R. Bruce Lydiard, PhD, MD;
Graham D. Burrows, MD;
Russell Noyes, Jr, MD;
Robert L. DuPont, Jr, MD
Arch Gen Psychiatry. 1988;45(5):437-443.
Abstract
| |
• Depressive symptomatology in 481 subjects with panic disorder and phobic avoidance was studied as part of an investigation of the efficacy of alprazolam in panic disorder. Subjects who had a major depressive episode (MDE) before the onset of their panic disorder were not included in the trial. With this exclusion criterion, 31% of subjects had a secondary MDE occurring after the onset of the panic disorder. The occurrence of secondary MDE was related to the length of time subjects were ill with panic disorder. Compared with the subjects without depression, those subjects with current MDE had higher scores on measures of anxiety and depression but not on the number of panic attacks per week. The presence of depression and the degree of phobic avoidance contributed independently to measures of the severity of the panic illness. Alprazolam was effective in reducing panic and depressive symptomatology in both depressed and nondepressed subjects with panic disorder. The presence of an MDE was not predictive of the outcome of treatment for the panic and phobic symptoms. Subjects with or without depression responded similarly to alprazolam.
Author Affiliations
From the Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, Calif (Drs Lesser and Rubin); Department of Psychiatry, St Mary's Hospital Center, Montreal (Dr Pecknold); Department of Psychiatry, Mount Sinai School of Medicine, New York (Dr Rifkin); Department of Psychiatry, Toronto General Hospital (Dr Swinson); Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (Dr Lydiard); Department of Psychiatry, University of Melbourne (Dr Burrows); Department of Psychiatry, University of Iowa, Iowa City (Dr Noyes); and Institute for Behavior and Health Inc, Rockville, Md (Dr DuPont).
Footnotes
Accepted for publication Feb 4, 1988.
Reprint requests to Department of Psychiatry, Harbor-UCLA Medical Center, Bldg D-5, 1000 W Carson St, Torrance, CA 90509 (Dr Lesser).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Generalized Anxiety Disorder in Patients With Major Depression: Is DSM-IV's Hierarchy Correct?
Zimmerman and Chelminski
Am. J. Psychiatry 2003;160:504-512.
ABSTRACT
| FULL TEXT
A 28-Year-Old Woman With Panic Disorder
Gorman
JAMA 2001;286:450-457.
FULL TEXT
Differences Between Clinical and Research Practices in Diagnosing Borderline Personality Disorder
Zimmerman and Mattia
Am. J. Psychiatry 1999;156:1570-1574.
ABSTRACT
| FULL TEXT
Lifetime Panic-Depression Comorbidity in the National Comorbidity Survey
Kessler et al.
Arch Gen Psychiatry 1998;55:801-808.
ABSTRACT
| FULL TEXT
Agoraphobia, Simple Phobia, and Social Phobia in the National Comorbidity Survey
Magee et al.
Arch Gen Psychiatry 1996;53:159-168.
ABSTRACT
Suicide Attempts in Patients With Panic Disorder
Lepine et al.
Arch Gen Psychiatry 1993;50:144-149.
ABSTRACT
The Structured Clinical Interview for DSM-III-R (SCID) I: History, Rationale, and Description
Spitzer et al.
Arch Gen Psychiatry 1992;49:624-629.
ABSTRACT
Outcome of Panic Disorder: Relationship to Diagnostic Subtypes and Comorbidity
Noyes et al.
Arch Gen Psychiatry 1990;47:809-818.
ABSTRACT
Depression in Panic Disorder and Response to Alprazolam Therapy
Pyke
Arch Gen Psychiatry 1989;46:1053-1053.
ABSTRACT
The 'Efficacy' of Alprazolam in Panic Disorder and Agoraphobia: A Critique of Recent Reports
Marks et al.
Arch Gen Psychiatry 1989;46:668-670.
ABSTRACT
Overview of the Cross-National Collaborative Panic Study: I. Efficacy in Short-term Treatment
Klerman
Arch Gen Psychiatry 1988;45:407-412.
ABSTRACT
Alprazolam in Panic Disorder and Agoraphobia: Results From a Multicenter Trial: I. Efficacy in Short-term Treatment
Ballenger et al.
Arch Gen Psychiatry 1988;45:413-422.
ABSTRACT
|
