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A Controlled Magnetic Resonance Imaging Study

John R. Kelsoe, Jr, MD; Jean Lud Cadet, MD; David Pickar, MD; Daniel R. Weinberger, MD

Arch Gen Psychiatry. 1988;45(6):533-541.

Abstract
• Twenty-four patients with schizophrenia and 14 normal control subjects underwent magnetic resonance imaging scans using a 0.5-tesla scanner and 600-ms inversion recovery technique. A midsagittal section and twelve 1-cm coronal sections beginning at the frontal pole were obtained, and linear, area, and signal intensity measurements were made on nine brain regions. Volume estimates were made by summing consecutive sections for four of the following regions: the precallosal frontal lobes, temporal lobes, lateral ventricles, amygdala-hippocampal complexes, and cerebral hemispheres. The area of the third ventricle in its most anterior coronal slice was increased by 73% in schizophrenic subjects (0.83 ±0.08 cm²) in comparison with controls (0.48 ±0.04 cm²) Lateral ventricular volume was increased by 62% in schizophrenic subjects (24.7 ±2.6 mL) in comparison with controls (15.2 ±1.4 mL). The lateral ventricular enlargement in schizophrenic subjects was more pronounced posteriorly than anteriorly, especially at the level of the anterior thalamus and the colliculi. There were no other significant differences between schizophrenic and control groups in any other spatial or signal intensity measures. There was no brain region the size of which correlated with ventricular size. These data corroborate third and lateral ventriculomegaly in schizophrenia using magnetic resonance imaging but fail to further localize the structural abnormality.

Author Affiliations
From the Section on Clinical Studies, Clinical Neuroscience Branch (Drs Kelsoe and Pickar), and the Clinical Brain Disorders Branch (Dr Weinberger), National Institute of Mental Health, Bethesda, Md; and the Department of Neurology, Columbia University School of Medicine, New York (Dr Cadet).

Footnotes
Accepted for publication Nov 20, 1987.

Presented in part before the Annual Meeting of the American Psychiatric Association, Chicago, May 14, 1987.

Reprint requests to Clinical Neuroscience Branch, National Institute of Mental Health, Bldg 10, Room 4N214, 9000 Rockville Pike, Bethesda, MD 20892 (Dr Kelsoe).

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