Plasma Homovanillic Acid as a Predictor of Response to Neuroleptics

doi:10.1001/archpsyc.1988.01800300060007

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 45 No. 6, June 1988

Online Only
	•	Online First Table of Contents

ORIGINAL ARTICLES

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (152)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Plasma Homovanillic Acid as a Predictor of Response to Neuroleptics

Ricardo Davila, PhD; Eliseo Manero, MD; Mercedes Zumarraga, MA; Isabel Andia, MA; Jack W. Schweitzer, PhD; Arnold J. Friedhoff, MD

Arch Gen Psychiatry. 1988;45(6):564-567.

Abstract

• Fourteen schizophrenic subjects were evaluated for degreeof psychosis before and after treatment with the antipsychoticdrug haloperidol and for plasma homovanillic acid concentrationafter four and 28 days of treatment. A significant correlationwas found between an increase in homovanillic acid concentrationon day 4 or a decrease from day 4 to day 28 and the degree ofimprovement after four weeks of treatment. Thus, those patientswho had the greatest change in plasma homovanillic acid in responseto neuroleptic blockade showed the greatest improvement. Theseand other observations have led us to propose that the centraldopaminergic system, through adaptive changes in activity, servesas a physiologic buffer system protecting against destabilizationof mental function from diverse biologic or psychologic insults.

Author Affiliations

From the Centro de Investigacion Neuroquimica, Osakidetza Gobierno Vasco, Zamudio, Spain (Drs Davila and Manero and Mss Zumarraga and Andia); and the Millhauser Laboratories, Department of Psychiatry, New York University School of Medicine (Drs Schweitzer and Friedhoff).

Footnotes

Accepted for publication Jan 28, 1988.

Reprint requests to Millhauser Laboratories, 550 First Ave,New York, NY 10016 (Dr Friedhoff).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Review: The biological basis of antipsychotic response in schizophrenia
Stone et al.
J Psychopharmacol 2010;24:953-964.
ABSTRACT

Effects of the Antipsychotic Risperidone on Dopamine Synthesis in Human Brain Measured by Positron Emission Tomography with L-[{beta}-11C]DOPA: A Stabilizing Effect for Dopaminergic Neurotransmission?
Ito et al.
J. Neurosci. 2009;29:13730-13734.
ABSTRACT | FULL TEXT

Neuroleptic Treatment of Agitation and Psychosis in Dementia
Devanand and Levy
J Geriatr Psychiatry Neurol 1995;8:S18-S27.
ABSTRACT

Plasma Homovanillic Acid Levels in First-Episode Schizophrenia: Psychopathology and Treatment Response
Koreen et al.
Arch Gen Psychiatry 1994;51:132-138.
ABSTRACT

Effects of Metabolic Perturbation on Plasma Homovanillic Acid in Schizophrenia: Relationship to Prefrontal Cortex Volume
Breier et al.
Arch Gen Psychiatry 1993;50:541-550.
ABSTRACT

Clinical and Biologic Response to Clozapine in Patients With Schizophrenia: Crossover Comparison With Fluphenazine
Pickar et al.
Arch Gen Psychiatry 1992;49:345-353.
ABSTRACT

Effects of Neuroleptic Treatment on Symptoms of Schizophrenia and Plasma Homovanillic Acid Concentrations
Davidson et al.
Arch Gen Psychiatry 1991;48:910-913.
ABSTRACT

Changes in Plasma Homovanillic Acid Concentrations in Schizophrenic Patients Following Neuroleptic Discontinuation
Davidson et al.
Arch Gen Psychiatry 1991;48:73-76.
ABSTRACT

Cerebrospinal Fluid and Plasma Monoamine Metabolites and Their Relation to Psychosis: Implications for Regional Brain Dysfunction in Schizophrenia
Pickar et al.
Arch Gen Psychiatry 1990;47:641-648.
ABSTRACT

Circadian Variation of Plasma Homovanillic Acid Levels Is Attentuated by Fluphenazine in Patients With Schizophrenia
Doran et al.
Arch Gen Psychiatry 1990;47:558-563.
ABSTRACT

Norepinephrine in Acute Exacerbations of Chronic Schizophrenia: Negative Symptoms Revisited
van Kammen et al.
Arch Gen Psychiatry 1990;47:161-168.
ABSTRACT

Effects of Renal Clearance on Plasma Concentrations of Homovanillic Acid: Methodologic Cautions
Potter et al.
Arch Gen Psychiatry 1989;46:558-562.
ABSTRACT

Plasma Monoamine Metabolites in Psychotic Disorders
Bowers
Arch Gen Psychiatry 1988;45:595-596.
ABSTRACT

| | |