This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Daniel J. Buysse, MD; Charles F. Reynolds III, MD; David J. Kupfer, MD; Patricia R. Houck, MSH; Carolyn C. Hoch, PhD; Jacqueline A. Stack, MSN; Susan R. Berman

Arch Gen Psychiatry. 1988;45(6):568-575.

Abstract
• Twenty-six patients with mixed symptoms of depression and cognitive impairment were studied with serial clinical ratings and sleep electroencephalograms during a one-night sleep-deprivation procedure. A subgroup of these patients with depressive pseudodementia (n = 8) had less severe symptoms of dementia at baseline and showed significant improvements in both Hamilton Depression Rating Scale scores and Profile of Mood States tension scores following sleep deprivation, while another subgroup of patients having primary degenerative dementia with depression (n =18) showed no change or worsening in Hamilton depression and Profile of Mood States tension ratings. Baseline sleep measures demonstrated significantly higher rapid eye movement (REM) percent and phasic REM activity/intensity in pseudodemented compared with demented patients. While both groups had increases in sleep efficiency, sleep maintenance, and slowwave sleep following sleep deprivation, recovery night 2 was characterized by greater first REM period duration in depressive pseudodementia than in dementia. These differences in REM sleep rebound (using an REM period 1 cutoff of 25 minutes) permitted correct identification of 88.5% of patients. Implications of these data for current theories regarding sleep, aging, and psychopathology are discussed.

Author Affiliations
From the Department of Psychiatry, University of Pittsburgh School of Medicine.

Footnotes
Accepted for publication Feb 10, 1988.

Reprint requests to Sleep Evaluation Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213 (Dr Reynolds).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Sleep and Psychiatric Disorders: A Meta-analysis
Benca et al.
Arch Gen Psychiatry 1992;49:651-668.
ABSTRACT  

Rapid Eye Movement Sleep Deprivation as a Probe in Elderly Subjects
Reynolds et al.
Arch Gen Psychiatry 1990;47:1128-1136.
ABSTRACT  

Two Roads to Rapid Eye Movement Latency
Kupfer and Ehlers
Arch Gen Psychiatry 1989;46:945-948.
ABSTRACT