 |
|
Computed Tomographic Evidence for Generalized Sulcal and Ventricular Enlargement in Schizophrenia
Adolf Pfefferbaum, MD;
Robert B. Zipursky, MD;
Kelvin O. Lim, MD;
Leslie M. Zatz, MD;
Stephen M. Stahl, MD, PhD;
Terry L. Jernigan, PhD
Arch Gen Psychiatry. 1988;45(7):633-640.
Abstract
• Quantification of ventricular and sulcal volumes from the computed tomographic (CT) scans of 45 schizophrenic patients and 57 normal controls was carried out using a semiautomated computerized approach. The sizes of all cerebrospinal fluid spaces measured were significantly related to age in the control population. An age regression model was used to compare patients and controls. Schizophrenics had slightly larger ventricles and considerably larger sulci than controls. Enlargement of the ventricles and sulci was not correlated with measures of negative symptoms or neuropsychological Impairment. The CT scans of eight very ill chronically institutionalized schizophrenics were also analyzed. Their CT findings did not differ significantly from the larger group of schizophrenics studied. Our results show that the cerebral atrophy found in schizophrenia is diffuse in nature and does not relate clearly to measures of disease severity or chronicity.
Author Affiliations
From the Departments of Psychiatry (Drs Pfefferbaum, Zipursky, and Lim) and Radiology (Dr Zatz), Stanford University School of Medicine, and the Veterans Administration Medical Center (Drs Pfefferbaum, Zipursky, and Lim), Palo Alto, Calif; the Department of Psychiatry, University of California, San Diego, and Veterans Administration Medical Center, La Jolla, Calif (Dr Jernigan); and Merck Sharp & Dohme Research Laboratories, Harlow, Essex, United Kingdom (Dr Stahl).
Footnotes
Accepted for publication Jan 22, 1988.
Reprint requests to Veterans Administration Medical Center (116A), 3801 Miranda Ave, Palo Alto, CA 94304 (Dr Pfefferbaum).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Neurobiology of early psychosis
KESHAVAN et al.
Br. J. Psychiatry 2005;187:s8-s18.
ABSTRACT
| FULL TEXT
Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia
Garey et al.
J. Neurol. Neurosurg. Psychiatry 1998;65:446-453.
ABSTRACT
| FULL TEXT
Structural Magnetic Resonance Image Averaging in Schizophrenia
Wolkin et al.
Am. J. Psychiatry 1998;155:1064-1073.
ABSTRACT
| FULL TEXT
Cerebral Gray Matter Volume Deficits in First Episode Psychosis
Zipursky et al.
Arch Gen Psychiatry 1998;55:540-546.
ABSTRACT
| FULL TEXT
Frontal and Temporal Lobe Brain Volumes in Schizophrenia: Relationship to Symptoms and Clinical Subtype
Turetsky et al.
Arch Gen Psychiatry 1995;52:1061-1070.
ABSTRACT
Greater Abnormalities of Brain Cerebrospinal Fluid Volumes in Younger Than in Older Patients With Alzheimer's Disease
Sullivan et al.
Arch Neurol 1993;50:359-373.
ABSTRACT
Widespread Cerebral Gray Matter Volume Deficits in Schizophrenia
Zipursky et al.
Arch Gen Psychiatry 1992;49:195-205.
ABSTRACT
Magnetic Resonance Imaging in Schizophrenia: I. Volumetric Analysis of Brain and Cerebrospinal Fluid
Gur et al.
Arch Gen Psychiatry 1991;48:407-412.
ABSTRACT
Brain Size in Schizophrenia
Zipursky et al.
Arch Gen Psychiatry 1991;48:179-180.
ABSTRACT
Ventricular Enlargement in Schizophrenia Evaluated With Computed Tomographic Scanning: Effects of Gender, Age, and Stage of Illness
Andreasen et al.
Arch Gen Psychiatry 1990;47:1008-1015.
ABSTRACT
The Hippocampus and Parahippocampus in Schizophrenic, Suicide, and Control Brains
Altshuler et al.
Arch Gen Psychiatry 1990;47:1029-1034.
ABSTRACT
Structural Brain Abnormalities in Bipolar Affective Disorder: Ventricular Enlargement and Focal Signal Hyperintensities
Swayze et al.
Arch Gen Psychiatry 1990;47:1054-1059.
ABSTRACT
|
