This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

David L. Braff, MD; Leighton Huey, MD

Arch Gen Psychiatry. 1988;45(9):827-832.

Abstract
• To examine the relationship of aminergic overactivity to information processing, we gave methylphenidate hydrochloride, oxazepam, or placebo to 12 nonpsychotic patients in one-week blocks in a double-blind, randomized design. Methylphenidate induced a pattern of information processing dysfunction similar to that seen in schizophrenic patients, strengthening the linkage of the schizophrenia—information processing dysfunction—aminergic overactivity relationship. Further, the time course of the observed deficits in both schizophrenic and methylphenidate-induced states is strikingly compatible with the temporal mapping pattern of monoaminergic neuronal systems. More research is needed to identify definitively the aminergic influences on attentional functioning. A psychophysical task—pharmacologic probe strategy should prove useful.

Author Affiliations
From the Department of Psychiatry, University of California, San Diego, La Jolla.

Footnotes
Accepted for publication March 30, 1988.

Reprint requests to Department of Psychiatry, T-004, University of California, San Diego, La Jolla, CA 92093 (Dr Braff).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Clinical Management of Attention Deficit Hyperactivity Disorder
Voeller
J Child Neurol 1991;6:S51-S67.
ABSTRACT  

Information Processing Deficit in Schizophrenia: A Frontal Lobe Sign?
Merriam et al.
Arch Gen Psychiatry 1989;46:760-760.
ABSTRACT