Lithium Treatment and Serotoninergic Function: Neuroendocrine and Behavioral Responses to Intravenous Tryptophan in Affective Disorder

doi:10.1001/archpsyc.1989.01810010015002

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Vol. 46 No. 1, January 1989

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Lithium Treatment and Serotoninergic Function

Neuroendocrine and Behavioral Responses to Intravenous Tryptophan in Affective Disorder

Lawrence H. Price, MD; Dennis S. Charney, MD; Pedro L. Delgado, MD; George R. Heninger, MD

Arch Gen Psychiatry. 1989;46(1):13-19.

Abstract

• Evidence suggests that lithium treatment alters serotoninergic(5-HT) function in laboratory animals and humans. Since 5-HTfunction may be abnormal in patients with affective disorders,we studied 23 such patients by measuring responses to intravenousinfusion of the 5-HT precursor tryptophan before and duringshort-term (less than one week) or long-term (greater than threeweeks) lithium treatment. The prolactin response to tryptophanwas significantly enhanced after short-term lithium treatment;long-term lithium treatment had no effect. Other studies haveshown that the prolactin response to tryptophan is also enhancedafter long-term tricyclic antidepressant treatment in depressedpatients and after short- and long-term lithium treatment inhealthy subjects. The present findings suggest that lithiumtreatment enhances 5-HT function, but that homeostatic responsesof the 5-HT system to long-term lithium treatment may differin patients with affective disorder and healthy subjects.

Author Affiliations

From the Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, and the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn.

Footnotes

Accepted for publication May 27, 1988.

Reprint requests to Connecticut Mental Health Center, 34 ParkSt, New Haven, CT 06508 (Dr Price).

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