Maternal Influenza in the Etiology of Schizophrenia

doi:10.1001/archpsyc.1989.01810100020004

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Vol. 46 No. 10, October 1989

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Maternal Influenza in the Etiology of Schizophrenia

R. E. Kendell, MD, FRCP, FRCPsych; I. W. Kemp, MD, FFCM

Arch Gen Psychiatry. 1989;46(10):878-882.

Abstract

• There are epidemiological reasons for suspecting thatinfections may contribute to the etiology of schizophrenia,and it is claimed that the birth cohort that was in utero duringthe 1957 influenza epidemic in Helsinki, Finland, now has anincreased incidence of schizophrenia. Three studies, all basedon the admission statistics of Scottish psychiatric hospitals,were therefore undertaken to determine whether those who werein utero during the influenza A epidemics of 1918 to 1919 and1957 were subsequently at increased risk of schizophrenia. Edinburghdata suggest that those who were in the sixth month of intrauterinedevelopment during the 1957 epidemic were subsequently at increasedrisk, but Scottish national data do not reveal any increasedrisk associated with either the 1918 to 1919 or 1957 epidemics.Overall, the hypothesis that maternal influenza may contributeto the etiology of schizophrenia is not supported, but the possibilitycannot yet be discounted.

Author Affiliations

From the Department of Psychiatry, Royal Edinburgh Hospital, Scotland.

Footnotes

Accepted for publication April 20, 1989.

Reprint requests to Department of Psychiatry, The Kennedy Tower,Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH105HF Scotland (Dr Kendell).

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