This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Tyrone D. Cannon, MA; Sarnoff A. Mednick, PhD, DrMed; Josef Parnas, MD

Arch Gen Psychiatry. 1989;46(10):883-889.

Abstract
• Using a subsample from the Copenhagen schizophrenia high-risk project, we examined the contributions of schizophrenic genetic liability and perinatal complications to computed tomographic (CT) measurements of ventricular enlargement and cortical and cerebellar abnormalities. A factor analysis of six CT measurements yielded two significant factors. One factor reflected multisite neural deficits as evidenced by abnormality of the cerebellar vermis and widening of the sylvian and interhemispheric fissures and cortical sulci. The other factor reflected periventricular damage as evidenced by enlargement of the third and lateral ventricles. Because all of the subjects had schizophrenic mothers, the major source of genetic variation is contributed by the diagnostic status of their fathers. In a stepwise multiple-regression analysis, it was determined that the multisite neural deficits factor was significantly related to genetic risk for schizophrenia (as measured by schizophrenia spectrum illness in the subjects' fathers) but was unrelated to pregnancy or delivery complications or to weight at birth. Periventricular damage was highly and significantly correlated with the number of complications suffered at delivery, but only among subjects with an elevated genetic risk. Although limited by a small sample size, these results suggest that the two types of CT abnormalities in schizophrenia may reflect partially independent processes based on different combinations of genetic and perinatal influences.

Author Affiliations
From the Social Science Research Institute, University of Southern California, Los Angeles (Mr Cannon and Dr Mednick), and Psykologisk Institut, Kommunehospitalet, Copenhagen, Denmark (Drs Mednick and Parnas).

Footnotes
Accepted for publication December 13, 1988.

Read in part before the Second International Congress on Schizophrenia Research, San Diego, Calif, April 5, 1989.

Reprint requests to Social Science Research Institute, University of Southern California, University Park, Los Angeles, CA 90089-MC-1111 (Mr Cannon).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Progression of Brain Volume Changes in Adolescent-Onset Psychosis
Reig et al.
Schizophr Bull 2009;35:233-243.
ABSTRACT | FULL TEXT  

Brain Structure and Function Changes During the Development of Schizophrenia: The Evidence From Studies of Subjects at Increased Genetic Risk
Lawrie et al.
Schizophr Bull 2008;34:330-340.
ABSTRACT | FULL TEXT  

Evaluating the Effects of Birth Complications on Low Self-Control in a Sample of Twins
Beaver and Wright
Int J Offender Ther Comp Criminol 2005;49:450-471.
ABSTRACT  

Childhood Videotaped Social and Neuromotor Precursors of Schizophrenia: A Prospective Investigation
Schiffman et al.
Am. J. Psychiatry 2004;161:2021-2027.
ABSTRACT | FULL TEXT  

Low Olfactory Bulb Volume in First-Degree Relatives of Patients With Schizophrenia
Turetsky et al.
Am. J. Psychiatry 2003;160:703-708.
ABSTRACT | FULL TEXT  

From the Cover: Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia
Thompson et al.
Proc. Natl. Acad. Sci. USA 2001;98:11650-11655.
ABSTRACT | FULL TEXT  

Obstetric complications and schizophrenia: prenatal underdevelopment and subsequent neurodevelopmental impairment
KUNUGI et al.
Br. J. Psychiatry 2001;178 :s25-s29.
ABSTRACT | FULL TEXT  

Supra-regional Brain Systems and the Neuropathology of Schizophrenia
Wright et al.
Cereb Cortex 1999;9:366-378.
ABSTRACT | FULL TEXT  

Minor Physical Anomalies, Dermatoglyphic Asymmetries, and Cortisol Levels in Adolescents With Schizotypal Personality Disorder
Weinstein et al.
Am. J. Psychiatry 1999;156:617-623.
ABSTRACT | FULL TEXT  

Regional Gray Matter, White Matter, and Cerebrospinal Fluid Distributions in Schizophrenic Patients, Their Siblings, and Controls
Cannon et al.
Arch Gen Psychiatry 1998;55:1084-1091.
ABSTRACT | FULL TEXT  

Developmental Brain Abnormalities in the Offspring of Schizophrenic Mothers: II. Structural Brain Characteristics of Schizophrenia and Schizotypal Personality Disorder
Cannon et al.
Arch Gen Psychiatry 1994;51:955-962.
ABSTRACT  

Neuropsychological Functioning in Siblings Discordant for Schizophrenia and Healthy Volunteers
Cannon et al.
Arch Gen Psychiatry 1994;51:651-661.
ABSTRACT  

Children at Risk for Schizophrenia: The Jerusalem Infant Development Study: II. Neurobehavioral Deficits at School Age
Marcus et al.
Arch Gen Psychiatry 1993;50:797-809.
ABSTRACT  

Developmental Brain Abnormalities in the Offspring of Schizophrenic Mothers: I. Contributions of Genetic and Perinatal Factors
Cannon et al.
Arch Gen Psychiatry 1993;50:551-564.
ABSTRACT  

Brain Morphology, Dopamine, and Eye-Tracking Abnormalities in First-Episode Schizophrenia: Prevalence and Clinical Correlates
Lieberman et al.
Arch Gen Psychiatry 1993;50:357-368.
ABSTRACT  

Schizophrenia After Prenatal Exposure to the Dutch Hunger Winter of 1944-1945
Susser and Lin
Arch Gen Psychiatry 1992;49:983-988.
ABSTRACT  

Volumes of Ventricular System Subdivisions Measured From Magnetic Resonance Images in First-Episode Schizophrenic Patients
Degreef et al.
Arch Gen Psychiatry 1992;49:531-537.
ABSTRACT  

Infants at Risk for Schizophrenia: Sequelae of a Genetic Neurointegrative Defect: A Review and Replication Analysis of Pandysmaturation in the Jerusalem Infant Development Study
Fish et al.
Arch Gen Psychiatry 1992;49:221-235.
ABSTRACT  

Antecedents of Predominantly Negativeand Predominantly Positive-Symptom Schizophrenia in a High-Risk Population
Cannon et al.
Arch Gen Psychiatry 1990;47:622-632.
ABSTRACT