This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Morphometric Study

Dilip V. Jeste, MD; James B. Lohr, MD

Arch Gen Psychiatry. 1989;46(11):1019-1024.

Abstract
• We studied hippocampal sections from 13 schizophrenic patients, 9 nonschizophrenic patients, and 16 normal controls from the Yakovlev brain collection. The three groups were similar in age, gender distribution, and brain weight. Most patients had never received neuroleptics, and the two patient groups had had similar types of leukotomies. We used a semiautomated image analysis system to compute volume and pyramidal-cell density in each of the four sectors of the cornu ammonis, CA₁ through CA₄, in the right and left hippocampi. Sections from schizophrenic patients had almost consistently the lowest volume and pyramidal-cell density in all sectors. The differences were greatest in left CA₄, with schizophrenic patients having significantly lower pyramidal-cell density than normal controls and significantly lower volume than leukotomy controls. Our findings confirm the results of several recent studies showing hippocampal pathologic features in schizophrenia. Our study suggests, however, that the hippocampal neuropathologic findings in schizophrenia may be more subtle and more localized than those reported previously.

Author Affiliations
From the Psychiatry Service, Veterans Administration Medical Center, San Diego, Calif.

Footnotes
Accepted for publication September 26, 1988.

Reprint requests to Psychiatry Service, V-116A, Veterans Administration Medical Center, San Diego, CA 92161 (Dr Jeste).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hippocampal Volumes in First-Episode Psychosis
Verma et al.
J. Neuropsychiatry Clin. Neurosi. 2009;21:24-29.
ABSTRACT | FULL TEXT  

Maternal infection and fever during late gestation are associated with altered synaptic transmission in the hippocampus of juvenile offspring rats
Lowe et al.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008;295:R1563-R1571.
ABSTRACT | FULL TEXT  

Limbic Structures and Networks in Children and Adolescents With Schizophrenia
White et al.
Schizophr Bull 2008;34:18-29.
ABSTRACT | FULL TEXT  

Regional Deficits in Brain Volume in Schizophrenia: A Meta-Analysis of Voxel-Based Morphometry Studies
Honea et al.
Am. J. Psychiatry 2005;162:2233-2245.
ABSTRACT | FULL TEXT  

Adult Neurogenesis: From Precursors to Network and Physiology
Abrous et al.
Physiol. Rev. 2005;85:523-569.
ABSTRACT | FULL TEXT  

Cavum Septum Pellucidum and Its Increased Prevalence in Schizophrenia: A Neuroembryological Classification
Galarza et al.
J. Neuropsychiatry Clin. Neurosi. 2004;16:41-46.
ABSTRACT | FULL TEXT  

Smaller Anterior Hippocampal Formation Volume in Antipsychotic-Naive Patients With First-Episode Schizophrenia
Szeszko et al.
Am. J. Psychiatry 2003;160:2190-2197.
ABSTRACT | FULL TEXT  

Size of hippocampal pyramidal neurons in schizophrenia
HIGHLEY et al.
Br. J. Psychiatry 2003;183:414-417.
ABSTRACT | FULL TEXT  

Schizophrenia
Freedman
NEJM 2003;349:1738-1749.
FULL TEXT  

White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction
Davis et al.
Arch Gen Psychiatry 2003;60:443-456.
ABSTRACT | FULL TEXT  

Estimated Neuronal Populations and Volumes of the Hippocampus and Its Subfields in Schizophrenia
Walker et al.
Am. J. Psychiatry 2002;159:821-828.
ABSTRACT | FULL TEXT  

Neuropsychological Correlates of Hippocampal Volumes in Patients Experiencing a First Episode of Schizophrenia
Szeszko et al.
Am. J. Psychiatry 2002;159:217-226.
ABSTRACT | FULL TEXT  

Supra-regional Brain Systems and the Neuropathology of Schizophrenia
Wright et al.
Cereb Cortex 1999;9:366-378.
ABSTRACT | FULL TEXT  

Gender Differences in Temporal Lobe Structures of Patients With Schizophrenia: A Volumetric MRI Study
Bryant et al.
Am. J. Psychiatry 1999;156:603-609.
ABSTRACT | FULL TEXT  

The neuropathology of schizophrenia: A critical review of the data and their interpretation
Harrison
Brain 1999;122:593-624.
ABSTRACT | FULL TEXT  

Hippocampal Volume in First-Episode Psychoses and Chronic Schizophrenia: A High-Resolution Magnetic Resonance Imaging Study
Velakoulis et al.
Arch Gen Psychiatry 1999;56:133-141.
ABSTRACT | FULL TEXT  

Forgetting rates in neuropsychiatric disorders
Lewis and Kopelman
J. Neurol. Neurosurg. Psychiatry 1998;65:890-898.
ABSTRACT | FULL TEXT  

Common Pattern of Cortical Pathology in Childhood-Onset and Adult-Onset Schizophrenia as Identified by Proton Magnetic Resonance Spectroscopic Imaging
Bertolino et al.
Am. J. Psychiatry 1998;155:1376-1383.
ABSTRACT | FULL TEXT  

Hippocampal morphometry in schizophrenia by high dimensional brain mapping
Csernansky et al.
Proc. Natl. Acad. Sci. USA 1998;95:11406-11411.
ABSTRACT | FULL TEXT  

Hippocampal Volume Reduction in Schizophrenia as Assessed by Magnetic Resonance Imaging: A Meta-analytic Study
Nelson et al.
Arch Gen Psychiatry 1998;55:433-440.
ABSTRACT | FULL TEXT  

Structural Magnetic Resonance Imaging Abnormalities in Men With Severe Chronic Schizophrenia and an Early Age at Clinical Onset
Marsh et al.
Arch Gen Psychiatry 1997;54:1104-1112.
ABSTRACT  

Rhesus Incompatibility as a Risk Factor for Schizophrenia in Male Adults
Hollister et al.
Arch Gen Psychiatry 1996;53:19-24.
ABSTRACT  

Glutamate Receptor Dysfunction and Schizophrenia
Olney and Farber
Arch Gen Psychiatry 1995;52:998-1007.
ABSTRACT  

Impaired Autonomic Nervous System Habituation in Those at Genetic Risk for Schizophrenia
Hollister et al.
Arch Gen Psychiatry 1994;51:552-558.
ABSTRACT  

Schizophrenia
Carpenter and Buchanan
NEJM 1994;330:681-690.
FULL TEXT  

Progress in Psychiatry- First of Two Parts
Michels and Marzuk
NEJM 1993;329:552-560.
FULL TEXT  

Distorted Distribution of Nicotinamide-Adenine Dinucleotide Phosphate--Diaphorase Neurons in Temporal Lobe of Schizophrenics Implies Anomalous Cortical Development
Akbarian et al.
Arch Gen Psychiatry 1993;50:178-187.
ABSTRACT  

Limbic System Abnormalities Identified in Schizophrenia Using Positron Emission Tomography With Fluorodeoxyglucose and Neocortical Alterations With Deficit Syndrome
Tamminga et al.
Arch Gen Psychiatry 1992;49:522-530.
ABSTRACT  

Psychiatric Disturbances in Metachromatic Leukodystrophy: Insights Into the Neurobiology of Psychosis
Hyde et al.
Arch Neurol 1992;49:401-406.
ABSTRACT  

Infants at Risk for Schizophrenia: Sequelae of a Genetic Neurointegrative Defect: A Review and Replication Analysis of Pandysmaturation in the Jerusalem Infant Development Study
Fish et al.
Arch Gen Psychiatry 1992;49:221-235.
ABSTRACT  

Abnormal Reinnervation as a Basis for Schizophrenia: A Hypothesis
Stevens
Arch Gen Psychiatry 1992;49:238-243.
ABSTRACT  

Hippocampal Neuron Number in Schizophrenia: A Stereological Study
Heckers et al.
Arch Gen Psychiatry 1991;48:1002-1008.
ABSTRACT  

Magnetic Resonance Imaging Abnormalities in Lenticular Nuclei and Cerebral Cortex in Schizophrenia
Jernigan et al.
Arch Gen Psychiatry 1991;48:881-890.
ABSTRACT  

Evidence of Reduced Temporolimbic Structure Volumes in Schizophrenia
BOGERTS et al.
Arch Gen Psychiatry 1991;48:956-957.
ABSTRACT  

Neuropsychological Function in Schizophrenia: Selective Impairment in Memory and Learning
Saykin et al.
Arch Gen Psychiatry 1991;48:618-624.
ABSTRACT  

Neuropathologic and Neurochemical Correlates of Psychosis in Primary Dementia
Zubenko et al.
Arch Neurol 1991;48:619-624.
ABSTRACT  

Limbic Structures and Lateral Ventricle in Schizophrenia: A Quantitative Postmortem Study
Heckers et al.
Arch Gen Psychiatry 1990;47:1016-1022.
ABSTRACT  

Developmental Abnormalities of the Corpus Callosum in Schizophrenia
Swayze et al.
Arch Neurol 1990;47:805-808.
ABSTRACT