This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Adolf Pfefferbaum, MD; Judith M. Ford, PhD; Patricia M. White; Walton T. Roth, MD

Arch Gen Psychiatry. 1989;46(11):1035-1044.

Abstract
• Eighteen schizophrenics who were not taking medication, 13 schizophrenics who were taking medication, and 37 agematched controls were tested with event-related potential paradigms designed to elicit P₃ response automatically or effortfully (ie, with a choice reaction time task). Electroencephalograms were recorded from the 19 standard 10-20 electrode sites. Compared with controls, both groups of schizophrenics had reduced P₃ amplitudes for both effortful and automatic paradigms. P_, latencies were delayed relative to controls for the medicationtaking schizophrenics in the effortful paradigms. Negative symptoms derived from the Brief Psychiatric Rating Scale within 1 week of event-related potential testing correlated negatively with both auditory and visual P₃ amplitude in the subjects who were not taking medication. There was no evidence that P₃ is smaller over left temporal electrode sites in schizophrenics, as has been reported by others. P₃ amplitude reduction in schizophrenia is a robust psychobiological phenomenon that is present regardless of medication status or task demands.

Author Affiliations
From the Veterans Administration Medical Center, Palo Alto, Calif; and the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.

Footnotes
Accepted for publication September 19, 1988.

A preliminary report of these data was presented at the Fourth International Conference on Cognitive Neurosciences, Paris, France, June 15, 1987, and at the American College of Neuropsychopharmacology, San Juan, Puerto Rico, December 8, 1987.

Reprint requests to VAMC (116 A3), 3801 Miranda Ave, Palo Alto, CA 94304 (Dr Pfefferbaum).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Reductions in the N1 and P2 Auditory Event-Related Potentials in First-Hospitalized and Chronic Schizophrenia
Salisbury et al.
Schizophr Bull 2009;0:sbp003v1-sbp003.
ABSTRACT | FULL TEXT  

Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures
Turetsky et al.
Schizophr Bull 2007;33:69-94.
ABSTRACT | FULL TEXT  

Impaired P3 Generation Reflects High-Level and Progressive Neurocognitive Dysfunction in Schizophrenia
van der Stelt et al.
Arch Gen Psychiatry 2004;61:237-248.
ABSTRACT | FULL TEXT  

P300 and Genetic Risk for Schizophrenia
Winterer et al.
Arch Gen Psychiatry 2003;60:1158-1167.
ABSTRACT | FULL TEXT  

Association Between Smaller Left Posterior Superior Temporal Gyrus Volume on Magnetic Resonance Imaging and Smaller Left Temporal P300 Amplitude in First-Episode Schizophrenia
McCarley et al.
Arch Gen Psychiatry 2002;59:321-331.
ABSTRACT | FULL TEXT  

Impairment of willed actions and use of advance information for movement preparation in schizophrenia
Fuller and Jahanshahi
J. Neurol. Neurosurg. Psychiatry 1999;66:502-509.
ABSTRACT | FULL TEXT  

Left Temporal Lobe Dysfunction in Schizophrenia: Event-Related Potential and Behavioral Evidence From Phonetic and Tonal Dichotic Listening Tasks
Bruder et al.
Arch Gen Psychiatry 1999;56:267-276.
ABSTRACT | FULL TEXT  

First-Episode Schizophrenic Psychosis Differs From First-Episode Affective Psychosis and Controls in P300 Amplitude Over Left Temporal Lobe
Salisbury et al.
Arch Gen Psychiatry 1998;55:173-180.
ABSTRACT | FULL TEXT  

Impaired Mismatch Negativity Generation Reflects Widespread Dysfunction of Working Memory in Schizophrenia
Javitt et al.
Arch Gen Psychiatry 1995;52:550-558.
ABSTRACT  

Auditory P300 Abnormalities and Left Posterior Superior Temporal Gyrus Volume Reduction in Schizophrenia
McCarley et al.
Arch Gen Psychiatry 1993;50:190-197.
ABSTRACT  

Delay in P300 Latency in Patients with Organic Solvent Exposure
Morrow et al.
Arch Neurol 1992;49:315-320.
ABSTRACT  

Auditory P300 and Eye Tracking Dysfunction in Schizophrenic Pedigrees
Blackwood et al.
Arch Gen Psychiatry 1991;48:899-909.
ABSTRACT  

Neuropsychological Function in Schizophrenia: Selective Impairment in Memory and Learning
Saykin et al.
Arch Gen Psychiatry 1991;48:618-624.
ABSTRACT  

Is There P300 Asymmetry in Schizophrenia?-Reply
Pfefferbaum et al.
Arch Gen Psychiatry 1991;48:381-383.
ABSTRACT  

Is There P300 Asymmetry in Schizophrenia?
McCarley et al.
Arch Gen Psychiatry 1991;48:380-381.
ABSTRACT