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  Vol. 46 No. 11, November 1989 TABLE OF CONTENTS
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P3 in Schizophrenia Is Affected by Stimulus Modality, Response Requirements, Medication Status, and Negative Symptoms

Adolf Pfefferbaum, MD; Judith M. Ford, PhD; Patricia M. White; Walton T. Roth, MD

Arch Gen Psychiatry. 1989;46(11):1035-1044.


Abstract

• Eighteen schizophrenics who were not taking medication, 13 schizophrenics who were taking medication, and 37 agematched controls were tested with event-related potential paradigms designed to elicit P3 response automatically or effortfully (ie, with a choice reaction time task). Electroencephalograms were recorded from the 19 standard 10-20 electrode sites. Compared with controls, both groups of schizophrenics had reduced P3 amplitudes for both effortful and automatic paradigms. P, latencies were delayed relative to controls for the medicationtaking schizophrenics in the effortful paradigms. Negative symptoms derived from the Brief Psychiatric Rating Scale within 1 week of event-related potential testing correlated negatively with both auditory and visual P3 amplitude in the subjects who were not taking medication. There was no evidence that P3 is smaller over left temporal electrode sites in schizophrenics, as has been reported by others. P3 amplitude reduction in schizophrenia is a robust psychobiological phenomenon that is present regardless of medication status or task demands.



Author Affiliations

From the Veterans Administration Medical Center, Palo Alto, Calif; and the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.


Footnotes

Accepted for publication September 19, 1988.

A preliminary report of these data was presented at the Fourth International Conference on Cognitive Neurosciences, Paris, France, June 15, 1987, and at the American College of Neuropsychopharmacology, San Juan, Puerto Rico, December 8, 1987.

Reprint requests to VAMC (116 A3), 3801 Miranda Ave, Palo Alto, CA 94304 (Dr Pfefferbaum).



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