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A Preliminary Report

Frank H. Gawin, MD; David Allen, MD; Brian Humblestone, MB

Arch Gen Psychiatry. 1989;46(4):322-325.

Abstract
• "Crack" cocaine abuse often produces severe cocaine dependence that is refractory to available pharmacological and outpatient psychotherapeutic treatments. We conducted two preliminary investigations evaluating the efficacy of flupenthixol decanoate, a depot xanthene requiring infrequent intramuscular administration, in the treatment of cocaine withdrawal. Ten outpatient crack cocaine smokers with poor prognoses were administered flupenthixol decanoate in an open-label, open-ended trial. Flupenthixol decanoate was well tolerated and appeared to decrease cocaine craving and use markedly and rapidly, producing a 260% increase in the average time retained in treatment among these subjects. These promising but preliminary data, combined with the magnitude of problems presented by crack, warrant rapid, expanded double-blind assessment of flupenthixol decanoate in cocaine-abuse treatment.

Author Affiliations
From the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn (Dr Gawin); and The Princess Margaret Hospital (Dr Allen) and The Sandilands Hospital (Dr Humblestone), Nassau, Bahamas.

Footnotes
Accepted for publication February 22, 1989.

Reprint requests to Substance Abuse Research Unit, Department of Psychiatry, Yale University School of Medicine, 27 Sylvan Ave, New Haven, CT 06519 (Dr Gawin).

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