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A Follow-up Study

Matti Virkkunen, MD; Judith De Jong, PhD; John Bartko, PhD; Frederick K. Goodwin, MD; Markku Linnoila, MD, PhD

Arch Gen Psychiatry. 1989;46(7):600-603.

Abstract
• Fifty-eight violent offenders and impulsive fire setters were followed up for an average of 3 years after release from prison. Recidivists who committed a new violent offense or arson had significantly lower cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid concentrations and blood glucose nadirs after oral glucose challenge than did nonrecidivists. A discriminant analysis, based on the blood glucose nadir and cerebrospinal fluid 5-hydroxyindoleacetic acid concentration, correctly classified 84.2% of the subjects.

Author Affiliations
From the Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism (Drs De Jong and Linnoila), Division of Biometry and Applied Sciences, National Institute of Mental Health (Dr Bartko), and Office of the Administrator, Alcohol, Drug Abuse and Mental Health Administration (Dr Goodwin), Bethesda, Md; and Department of Psychiatry, University of Helsinki, Finland (Dr Virkkunen).

Footnotes
Accepted for publication August 23, 1988.

Reprint requests to National Institutes of Health, Bldg 10, Room 3B19, 9000 Rockville Pike, Bethesda, MD 20892 (Dr Linnoila).

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