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A 5-Year Follow-up Study

Alec Roy, MB; Judith De Jong, PhD; Markku Linnoila, MD, PhD

Arch Gen Psychiatry. 1989;46(7):609-612.

Abstract
• We carried out a 5-year follow-up study of suicidal behavior among depressed patients who earlier had determinations of cerebrospinal fluid levels of monoamine metabolites. Patients who reattempted suicide during the follow-up had significantly lower cerebrospinal fluid levels of both the serotonin metabolite 5-hydroxyindoleacetic acid and the dopamine metabolite homovanillic acid. The findings were most striking among melancholic patients. These follow-up results suggest that reduced central turnover of serotonin and dopamine may be associated with further suicidal behavior among depressed patients who have previously attempted suicide.

Author Affiliations
From the Laboratory of Clinical Studies, Division of Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md.

Footnotes
Accepted for publication February 8, 1989.

Reprint requests to National Institute on Alcohol Abuse and Alcoholism, Bldg 10, Room 3B19, 9000 Rockville Pike, Bethesda MD 20892 (Dr Roy).

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