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Correlates With Indexes of Noradrenergic Function

Alec Roy, MB; Judith De Jong, PhD; Markku Linnoila, MD, PhD

Arch Gen Psychiatry. 1989;46(8):679-681.

Abstract
• Pathological gamblers may have a disturbance of their central nervous system noradrenergic functioning. We administered the Eysenck Personality Questionnaire to pathological gamblers and examined relationships between their personality scores on this questionnaire and indexes of noradrenergic function. There were highly significant correlations between scores on the extraversion scale and cerebrospinal fluid levels of 3-methoxy-4hydroxyphenylglycol, plasma levels of 3-methoxy-4-hydroxyphenylglycol, urinary outputs of vanillylmandelic acid, as well as with the sum of urinary outputs of norepinephrine and its major metabolites. These results suggest that the disturbance in the central noradrenergic system in pathological gamblers may be partly reflected in their personality.

Author Affiliations
From the Laboratory of Clinical Studies, Division of Intramural Clinical Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md.

Footnotes
Accepted for publication September 23, 1988.

Reprint requests to NIAAA, Bldg 10, Room 3B19, 9000 Rockville Pike, Bethesda, MD 20892 (Dr Roy).

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