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Anastasios Georgotas, MD; Robert E. McCue, MD; Thomas B. Cooper, MA

Arch Gen Psychiatry. 1989;46(9):783-786.

Abstract
• Fifty-one elderly depressed outpatients who had responded to antidepressants and completed continuation therapy were observed under double-blind conditions for 1 year. Twenty-three had been switched to placebo, while 13 and 15 took nortriptyline hydrochloride and phenelzine sulfate, respectively. Patients administered phenelzine did significantly better with 13.3% recurrences than patients administered either nortriptyline (53.8% recurrences) or placebo (65.2% recurrences). In addition, patients who had higher Hamilton scores and who had an earlier age of onset of the first depressive episode were significantly more likely to have recurrences.

Author Affiliations
From the Depression Studies Program, New York University School of Medicine, New York (Drs Georgotas and McCue); and College of Physicians and Surgeons, Columbia University, Analytical Psychopharmacology Laboratory, Nathan Kline Institute, and New York State Psychiatric Institute, New York (Mr Cooper).

Footnotes
Accepted for publication October 28, 1988.

Reprint requests to Department of Psychiatry, New York University Medical Center, 550 First Ave, New York, NY 10016 (Dr Georgotas).

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