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The 24-Hour Profile of Plasma Prolactin in Men With Major Endogenous Depressive Illness
Paul Linkowski, MD, PhD;
Eve Van Cauter, PhD;
Mireille L'Hermite-Baleriaux, MS;
Myriam Kerkhofs, MS;
Philippe Hubain, MD;
Marc L'Hermite, MD, PhD;
Julien Mendlewicz, MD, PhD
Arch Gen Psychiatry. 1989;46(9):813-819.
Abstract
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• Plasma prolactin (PRL) levels were measured at 15-minute intervals for 24 hours in 18 men suffering from major endogenous depressive illness and in 7 age-matched healthy men. Eleven of the 18 depressed patients were restudied during clinical remission following either electroconvulsive therapy or treatment with amitiptyline hydrochloride. During the acute phase of the illness, the unipolar depressed patients had fragmented patterns of PRL secretion with an early timing of the nocturnal secretory phase of PRL, which started, on the average, 2 hours earlier than in healthy subjects. Moreover, the amplitude of the circadian variation of PRL was reduced in these patients, with subnormal PRL levels occurring during the midsleep period. This latter abnormality was also observed in bipolar patients, who had otherwise normal PRL profiles. These lower midsleep PRL concentrations were associated with a significant increase in the amount of time spent awake during the same period. Antidepressant treatment did not consistently correct the abnormalities in the patterns of PRL release observed during the acute phase of the illness. These results indicate that early timing of nocturnal PRL secretion and damping of the nighttime PRL elevation may be found in men with endogenous depressive disorders. In contrast to disturbances of the corticotropic and somatotropic axes, these abnormalities of PRL secretion may still be present during clinical remission following antidepressant treatment.
Author Affiliations
From the Department of Psychiatry (Drs Linkowski, Hubain, and Mendlewicz and Ms Kerkhofs), Hôpital Erasme, Institute of Interdisciplinary Research (Dr Van Cauter), and Department of Gynecology and Obstetrics (Ms L'Hermite-Baleriaux and Dr L'Hermite ), Hôpital Brugmann, Université Libre de Bruxelles, Brussels, Belgium; and the Department of Medicine, the University of Chicago, Chicago, Ill (Dr Van Cauter),
Footnotes
Accepted for publication October 7, 1988.
Reprint requests to Department of Psychiatry, Hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium (Dr Linkowski).
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