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William Bondareff, PhD, MD; Janak Raval, MD; Buck Woo, PhD; Douglas L. Hauser; Patrick M. Colletti, MD

Arch Gen Psychiatry. 1990;47(1):47-51.

Abstract
• Periventricular white-matter lesions were visualized in the brains of elderly patients being assessed for possible Alzheimer's disease. The magnitude of these lesions, expressed as lesion-brain ratios, correlated closely with the severity of dementia indicated by scores on the Blessed Dementia Scale and the Folstein Mini-Mental State Examination. Impairment in several domains of cognitive functioning tested by the Mini-Mental State Examination was also correlated with the relative quantity of periventricular lesions. Correlations were significant with systolic blood pressure, approached significance with age, and were not significant with duration of dementia or the magnitude of the lateral ventricles. These findings indicate the potential utility of structure-function correlations that are possible with magnetic resonance imaging in identifying mechanisms underlying dementia. They suggest that magnetic resonance imaging may be more useful than computed tomography in following the course of dementia.

Author Affiliations
From the Division of Geriatric Psychiatry, Department of Psychiatry and the Behavioral Sciences (Dr Bondareff and Mr Hauser), and the Departments of Radiology (Drs Raval and Colletti) and Psychology (Dr Woo), University of Southern California, Los Angeles.

Footnotes
Accepted for publication February 13, 1989.

Reprint requests to Division of Geriatric Psychiatry, Department of Psychiatry and the Behavioral Sciences, USC School of Medicine, 2025 Zonal Ave, Los Angeles, CA 90033 (Dr Bondareff).

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