Subcortical Abnormalities Detected in Bipolar Affective Disorder Using Magnetic Resonance Imaging: Clinical and Neuropsychological Significance

doi:10.1001/archpsyc.1990.01810130057008

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Vol. 47 No. 1, January 1990

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Subcortical Abnormalities Detected in Bipolar Affective Disorder Using Magnetic Resonance Imaging

Clinical and Neuropsychological Significance

Renee M. Dupont, MD; Terry L. Jernigan, PhD; Nelson Butters, PhD; Dean Delis, PhD; John R. Hesselink, MD; William Heindel; J. Christian Gillin, MD

Arch Gen Psychiatry. 1990;47(1):55-59.

Abstract

• Magnetic resonance imaging was utilized to determinethe nature and rate of subcortical abnormalities in bipolaraffective disorder. Nine of 19 bipolar patients and no controlsdemonstrated subcortical signal hyperintensities on blind evaluationof the images. There was no apparent change in the appearanceof the hyperintensities in 7 of 7 subjects with abnormal magneticresonance images who underwent repeated imaging at 1 year. Bipolarpatients with abnormalities had a history of more hospitalizationsand appeared more impaired on tests of fluency and recall whencompared with bipolar patients without abnormalities or withcontrols. The possible etiology and significance of signal hyperintensitiesin bipolar affective disorder is discussed.

Author Affiliations

From the San Diego Veterans Administration Medical Center and the Department of Psychiatry, University of California, San Diego.

Footnotes

Accepted for publication August 14, 1989.

Reprint requests to Department of Psychiatry, M-003, Schoolof Medicine, University of California, San Diego, La Jolla,CA 92093 (Dr Dupont).

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