This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

I. Comparison of Major Depressives and Normal Controls at Rest

Harold A. Sackeim, PhD; Isak Prohovnik, PhD; James R. Moeller, PhD; Richard P. Brown, MD; Seth Apter, MA; Joan Prudic, MD; D. P. Devanand, MD; Sukdeb Mukherjee, MD

Arch Gen Psychiatry. 1990;47(1):60-70.

Abstract
• We measured regional cerebral blood flow with the xenon 133 inhalation technique in 41 patients with major depressive disorder and 40 matched, normal controls during an eyes-closed, resting condition. The depressed group had a marked reduction in global cortical blood flow. To examine topographic abnormalities, traditional multivariate analyses were applied, as well as a new scaled subprofile model developed to identify abnormal functional neural networks in clinical samples. Both approaches indicated that the depressed sample had an abnormality in topographic distribution of blood flow, in addition to the global deficit. The scaled subprofile model identified the topographic abnormality as being due to flow reduction in the depressed patients in selective frontal, central, superior temporal, and anterior parietal regions. This pattern may reflect dysfunction in the parallel distributed cortical network involving frontal and temporoparietal polymodal association areas. The extent of this topographic abnormality, as revealed by the scaled subprofile model, was associated with both patient age and severity of depressive symptoms.

Author Affiliations
From the Department of Biological Psychiatry, New York State Psychiatric Institute, New York (Drs Sackeim, Prohovnik, Moeller, Brown, Prudic, Devanand, and Mukherjee and Mr Apter); the Departments of Psychiatry (Drs Sackeim, Prohovnik, Moeller, Brown, Prudic, Devanand, and Mukherjee) and Neurology and Radiology (Dr Prohovnik), College of Physicians and Surgeons, Columbia University, New York; and the Departments of Neurology, Memorial Sloane-Kettering Cancer Center and Cornell University Medical Center, New York (Dr Moeller).

Footnotes
Accepted for publication July 28, 1989.

Reprint requests to Department of Biological Psychiatry, New York State Psychiatric Institute, 722 W 168th St, New York, NY 10032 (Dr Sackeim).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Regional Cerebral Blood Flow and Metabolic Rate in Persistent Lyme Encephalopathy
Fallon et al.
Arch Gen Psychiatry 2009;66:554-563.
ABSTRACT | FULL TEXT  

Psychiatric Comorbidities and Schizophrenia
Buckley et al.
Schizophr Bull 2009;35:383-402.
ABSTRACT | FULL TEXT  

Neuroanatomic Correlates of Psychopathologic Components of Major Depressive Disorder
Milak et al.
Arch Gen Psychiatry 2005;62:397-408.
ABSTRACT | FULL TEXT  

Localizing Gray Matter Deficits in Late-Onset Depression Using Computational Cortical Pattern Matching Methods
Ballmaier et al.
Am. J. Psychiatry 2004;161:2091-2099.
ABSTRACT | FULL TEXT  

Regional Cerebral Blood Flow and Cognitive Deficits in Chronic Lyme Disease
Fallon et al.
J. Neuropsychiatry Clin. Neurosi. 2003;15:326-332.
ABSTRACT | FULL TEXT  

Changes in Regional Cerebral Blood Flow With Venlafaxine in the Treatment of Major Depression
Davies et al.
Am. J. Psychiatry 2003;160:374-376.
ABSTRACT | FULL TEXT  

Cerebral haemodynamics and depression in the elderly
Tiemeier et al.
J. Neurol. Neurosurg. Psychiatry 2002;73:34-39.
ABSTRACT | FULL TEXT  

Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study
Beyer et al.
J Psychopharmacol 2002;16:297-304.
ABSTRACT  

Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric Depression
de Asis et al.
Am. J. Psychiatry 2001;158:1321-1323.
ABSTRACT | FULL TEXT  

Brain Blood Flow Changes in Depressed Patients Treated With Interpersonal Psychotherapy or Venlafaxine Hydrochloride: Preliminary Findings
Martin et al.
Arch Gen Psychiatry 2001;58:641-648.
ABSTRACT | FULL TEXT  

Functional Brain Circuits in Major Depression and Remission
Sackeim
Arch Gen Psychiatry 2001;58:649-650.
FULL TEXT  

Changes in Regional Brain Glucose Metabolism Measured With Positron Emission Tomography After Paroxetine Treatment of Major Depression
Kennedy et al.
Am. J. Psychiatry 2001;158:899-905.
ABSTRACT | FULL TEXT  

Alteration of Hemoglobin Oxygenation in the Frontal Region in Elderly Depressed Patients as Measured by Near-infrared Spectroscopy
Matsuo et al.
J. Neuropsychiatry Clin. Neurosi. 2000;12:465-471.
ABSTRACT | FULL TEXT  

Functional and Neuroanatomic Correlations in Poststroke Depression : The Sunnybrook Stroke Study
Singh et al.
Stroke 2000;31:637-644.
ABSTRACT | FULL TEXT  

Cerebral Blood Flow and Metabolism in Late-Life Depression and Dementia
Nobler et al.
J Geriatr Psychiatry Neurol 1999;12:118-127.
ABSTRACT  

Clinical Neurophysiology Using Electroencephalography in Geriatric Psychiatry: Neurobiologic Implications and Clinical Utility
Holschneider and Leuchter
J Geriatr Psychiatry Neurol 1999;12:150-164.
ABSTRACT  

Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI
Kumar et al.
Proc. Natl. Acad. Sci. USA 1998;95:7654-7658.
ABSTRACT | FULL TEXT  

Neuroanatomical Substrates of Late-Life Minor Depression: A Quantitative Magnetic Resonance Imaging Study
Kumar et al.
Arch Neurol 1997;54:613-617.
ABSTRACT  

Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion--Induced Depressive Relapse
Bremner et al.
Arch Gen Psychiatry 1997;54:364-374.
ABSTRACT  

Regional Cerebral Blood Flow in Mood Disorders, III: Treatment and Clinical Response
Nobler et al.
Arch Gen Psychiatry 1994;51:884-897.
ABSTRACT  

Reduction of Cerebral Blood Flow in Older Depressed Patients
Lesser et al.
Arch Gen Psychiatry 1994;51:677-686.
ABSTRACT  

Is there a distinct subtype of major depression in the elderly?
Baldwin
J Psychopharmacol 1994;8:177-184.
ABSTRACT  

Quantitative Cerebral Anatomy in Depression: A Controlled Magnetic Resonance Imaging Study
Coffey et al.
Arch Gen Psychiatry 1993;50:7-16.
ABSTRACT  

Neurobehavioral Probes for Physiologic Neuroimaging Studies
Gur et al.
Arch Gen Psychiatry 1992;49:409-414.
ABSTRACT