Regional Cerebral Blood Flow in Mood Disorders: I. Comparison of Major Depressives and Normal Controls at Rest

doi:10.1001/archpsyc.1990.01810130062009

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Vol. 47 No. 1, January 1990

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Regional Cerebral Blood Flow in Mood Disorders

I. Comparison of Major Depressives and Normal Controls at Rest

Harold A. Sackeim, PhD; Isak Prohovnik, PhD; James R. Moeller, PhD; Richard P. Brown, MD; Seth Apter, MA; Joan Prudic, MD; D. P. Devanand, MD; Sukdeb Mukherjee, MD

Arch Gen Psychiatry. 1990;47(1):60-70.

Abstract

• We measured regional cerebral blood flow with the xenon133 inhalation technique in 41 patients with major depressivedisorder and 40 matched, normal controls during an eyes-closed,resting condition. The depressed group had a marked reductionin global cortical blood flow. To examine topographic abnormalities,traditional multivariate analyses were applied, as well as anew scaled subprofile model developed to identify abnormal functionalneural networks in clinical samples. Both approaches indicatedthat the depressed sample had an abnormality in topographicdistribution of blood flow, in addition to the global deficit.The scaled subprofile model identified the topographic abnormalityas being due to flow reduction in the depressed patients inselective frontal, central, superior temporal, and anteriorparietal regions. This pattern may reflect dysfunction in theparallel distributed cortical network involving frontal andtemporoparietal polymodal association areas. The extent of thistopographic abnormality, as revealed by the scaled subprofilemodel, was associated with both patient age and severity ofdepressive symptoms.

Author Affiliations

From the Department of Biological Psychiatry, New York State Psychiatric Institute, New York (Drs Sackeim, Prohovnik, Moeller, Brown, Prudic, Devanand, and Mukherjee and Mr Apter); the Departments of Psychiatry (Drs Sackeim, Prohovnik, Moeller, Brown, Prudic, Devanand, and Mukherjee) and Neurology and Radiology (Dr Prohovnik), College of Physicians and Surgeons, Columbia University, New York; and the Departments of Neurology, Memorial Sloane-Kettering Cancer Center and Cornell University Medical Center, New York (Dr Moeller).

Footnotes

Accepted for publication July 28, 1989.

Reprint requests to Department of Biological Psychiatry, NewYork State Psychiatric Institute, 722 W 168th St, New York,NY 10032 (Dr Sackeim).

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