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Prednisone Effects on Neurochemistry and BehaviorPreliminary Findings
Owen M. Wolkowitz, MD;
David Rubinow, MD;
Allen R. Doran, MD;
Alan Breier, MD;
Wade H. Berrettini, MD, PhD;
Mitchel A. Kling, MD;
David Pickar, MD
Arch Gen Psychiatry. 1990;47(10):963-968.
Abstract
• To evaluate the neurochemical, neuroendocrine, and behavioral effects of exogenous corticosteroids in humans, we administered prednisone (80 mg/d orally for 5 days) in a double-blind manner to 12 medically healthy volunteers. Behavioral measures were assessed before, during, and after prednisone administration in all 12 subjects, and cerebrospinal fluid biochemistry was assessed before and during prednisone administration in 9 of the subjects. Prednisone administration was associated with decreases in cerebrospinal fluid levels of corticotropin, norepinephrine, β-endorphin, β-lipotropin, and somatostatinlike immunoreactivity. No significant changes were noted in cerebrospinal fluid levels of  -melanocyte-stimulating hormone, corticotropinreleasing hormone, 3-methoxy-4-hydroxyphenylglycol, homevanillic acid, or 5-hydroxyindoleacetic acid. No consistent or significant group mean changes were observed in structured behavioral ratings, although 9 (75%) of the volunteers studied reported mild behavioral changes while receiving prednisone. Correlations between the neurochemical and behavioral changes are discussed.
Author Affiliations
From the Department of Psychiatry, University of California, San Francisco (Dr Wolkowitz); the National Institute of Mental Health, Bethesda, Md (Drs Rubinow, Berrettini, Kling, and Pickar); the Department of Psychiatry, University of California, Davis, Sacramento (Dr Doran); and Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore (Dr Breier).
Footnotes
Accepted for publication October 18, 1989.
Read before the 26th Annual Meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico, December 9, 1987.
Reprint requests to Department of Psychiatry, University of California, San Francisco, 401 Parnassus Ave, San Francisco, CA 94143 (Dr Wolkowitz).
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