Delta Sleep Ratio: A Biological Correlate of Early Recurrence in Unipolar Affective Disorder

doi:10.1001/archpsyc.1990.01810240020004

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 47 No. 12, December 1990

Online Only
	•	Online First Table of Contents

ORIGINAL ARTICLES

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (162)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Delta Sleep Ratio

A Biological Correlate of Early Recurrence in Unipolar Affective Disorder

David J. Kupfer, MD; Ellen Frank, PhD; Ann B. McEachran, MS; Victoria J. Grochocinski, PhD

Arch Gen Psychiatry. 1990;47(12):1100-1105.

Abstract

• Slow wave sleep abnormalities have long been describedin depression but were considered to be nonspecific indicatorsof psychopathology. Computerized techniques, including amplitudefrequency measures and spectral analyses, are permitting newapproaches to the examination of delta sleep. Early studiessuggested that many depressed patients demonstrate lower deltawave intensity during the first non—rapid eye movementperiod than the second one. This finding, prominent in middle-ageddepressed patients, has led to an examination of the ratio betweenthe first and second non—rapid eye movement periods. Thisdelta sleep measure seems to be a more robust predictor of recurrencethan rapid eye movement latency. Analysis of data on 74 patientsin a long-term maintenance treatment study for a minimum of24 months demonstrates that the delta sleep ratio can predictsurvival time following discontinuation of drug treatment. Individualswith a high delta sleep ratio remain clinically remitted fivetimes longer than those with a low delta sleep ratio.

Author Affiliations

From the Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pa.

Footnotes

Accepted for publication November 21, 1989.

Reprint requests to Department of Psychiatry, University ofPittsburgh School of Medicine, Western Psychiatric Instituteand Clinic, 3811 O'Hara St, Pittsburgh, PA 15213 (Dr Kupfer).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Troubled Sleep, Troubled Minds, and DSM-5
Reynolds
Arch Gen Psychiatry 2011;68:990-991.
FULL TEXT

Alterations in Regional Cerebral Glucose Metabolism Across Waking and Non-Rapid Eye Movement Sleep in Depression
Nofzinger et al.
Arch Gen Psychiatry 2005;62:387-396.
ABSTRACT | FULL TEXT

The Neurobiology of Depression: Perspectives from Animal and Human Sleep Studies
Shaffery et al.
Neuroscientist 2003;9:82-98.
ABSTRACT

Treatment and Prevention of Depression
Hollon et al.
Psychological Science in the Public Interest 2002;3:39-77.
ABSTRACT

Electroencephalographic Sleep Profiles Before and After Cognitive Behavior Therapy of Depression
Thase et al.
Arch Gen Psychiatry 1998;55:138-144.
ABSTRACT | FULL TEXT

Temporal Profiles of the Course of Depression During Treatment: Predictors of Pathways Toward Recovery in the Elderly
Dew et al.
Arch Gen Psychiatry 1997;54:1016-1024.
ABSTRACT

Electroencephalographic Sleep Profiles During Depression: Effects of Episode Duration and Other Clinical and Psychosocial Factors in Older Adults
Dew et al.
Arch Gen Psychiatry 1996;53:148-156.
ABSTRACT

Effects of Hypericum Extract on the Sleep EEG in Older Volunteers
Schulz and Jobert
J Geriatr Psychiatry Neurol 1994;7:S39-S43.
ABSTRACT

Obstructive Sleep Apnoea and Depression -- Diagnostic and Treatment Implications
Kaplan
Aust N Z J Psychiatry 1992;26:586-591.
ABSTRACT

Sleep in Schizophrenic Patients On and Off Haloperidol Therapy: Clinically Stable vs Relapsed Patients
Neylan et al.
Arch Gen Psychiatry 1992;49:643-649.
ABSTRACT

The management of patients at risk for suicide
Abou-Saleh
J Psychopharmacol 1992;6:304-311.
ABSTRACT

Treatment of Recurrent Unipolar Major Depressive Disorder: Commentary on the Pittsburgh Study
Klerman
Arch Gen Psychiatry 1990;47:1158-1162.
ABSTRACT

| | |