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A Positron Emission Tomography Study With [11C]Raclopride

Lars Farde, MD; Frits-Axel Wiesel, MD; Sharon Stone-Elander, PhD; Christer Halldin, PhD; Anna-Lena Nordström, MD; HÅnkan Hall, PhD; Göran Sedvall, MD

Arch Gen Psychiatry. 1990;47(3):213-219.

Abstract
• Several groups have reported increased densities of D₂ dopamine receptors in the basal ganglia of schizophrenic brains postmortem. The significance of this finding has been questioned, since an upregulation of receptor number may be a neuronal response to neuroleptic drug treatment. We have used positron emission tomography and [¹¹ C]raclopride to examine central D₂ dopamine receptor binding in 20 healthy subjects and 18 newly admitted, young, neuroleptic-naive patients with schizophrenia. An in vivo saturation procedure was applied for quantitative determination of D₂ dopamine receptor density (B_max) and affinity (K_d). When the two groups were compared, no significant difference in B_max or K_d values was found in the putamen or the caudate nucleus. The hypothesis of generally elevated central D₂ dopamine receptor densities in schizophrenia was thus not supported by the present findings. In the patients but not in the healthy controls, significantly higher densities were found in the left than in the right putamen but not in the caudate nucleus.

Author Affiliations
From The Department of Psychiatry and Psychology, The Karolinska Institute, Stockholm, Sweden (Drs Farde, Wiesel, Nordström, and Sedvall); The Karolinska Pharmacy, Stockholm, Sweden (Drs Stone-Elander and Halldin); and Astra Research Center, Södertälje, Sweden (Dr Hall).

Footnotes
Accepted for publication October 18, 1989.

A preliminary report of this study was published in a letter to the ARCHIVES (1987;44:671-672).

Reprint requests to Department of Psychiatry and Psychology, The Karolinska Institute and Hospital, S-104 01, Stockholm, Sweden (Dr Farde).

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