This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Deborah S. Cowley, MD; George W. Arana, MD

Arch Gen Psychiatry. 1990;47(3):277-284.

Abstract
• Lactate infusion is the most extensively studied of the pharmacological challenge tests in panic disorder. We assessed the value of this test in the diagnosis and subtyping of panic in clinical and research settings. Analysis of lactate infusion studies to date suggests that patients with panic attacks are significantly more sensitive to lactate than are healthy controls or patients with other psychiatric disorders without panic attacks. However, the usefulness of lactate infusion is limited by the lack of standardized, objective criteria for lactate-induced panic and uncertainty as to the sensitivity and specificity of the test for current, clinically significant panic attacks. Except in rare cases, the clinical history is likely to be of more value than lactate response in diagnosing panic disorder. Determination of the role of the test in subtyping patients with panic disorder awaits further study of the diagnostic, prognostic, genetic, and pathophysiologic significance of lactate sensitivity.

Author Affiliations
From the Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle (Dr Cowley); and the Department of Psychiatry and Behavioral Science and the Institute of Psychiatry, Medical University of South Carolina, Columbia, and the Inpatient Service, Psychiatry Service, Charleston (SC) Veterans Administration Medical Center (Dr Arana).

Footnotes
Accepted for publication March 16, 1989.

Reprint requests to Department of Psychiatry and Behavioral Sciences RP-10, University of Washington, Seattle, WA 98195 (Dr Cowley).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior
Sajdyk et al.
J Psychopharmacol 2008;22:633-641.
ABSTRACT  

Pharmacological models in healthy volunteers: their use in the clinical development of psychotropic drugs
Gilles and Luthringer
J Psychopharmacol 2007;21:272-282.
ABSTRACT  

Angiotensin-II Is a Putative Neurotransmitter in Lactate-Induced Panic-Like Responses in Rats with Disruption of GABAergic Inhibition in the Dorsomedial Hypothalamus
Shekhar et al.
J. Neurosci. 2006;26:9205-9215.
ABSTRACT | FULL TEXT  

Dyspnea, Ventilatory Pattern, and Changes in Dynamic Hyperinflation Related to the Intensity of Constant Work Rate Exercise in COPD
Puente-Maestu et al.
Chest 2005;128:651-656.
ABSTRACT | FULL TEXT  

Ventilatory Physiology of Children and Adolescents With Anxiety Disorders
Pine et al.
Arch Gen Psychiatry 1998;55:123-129.
ABSTRACT | FULL TEXT  

The Structure of the Genetic and Environmental Risk Factors for Six Major Psychiatric Disorders in Women: Phobia, Generalized Anxiety Disorder, Panic Disorder, Bulimia, Major Depression, and Alcoholism
Kendler et al.
Arch Gen Psychiatry 1995;52:374-383.
ABSTRACT  

Enhanced Sensitivity to Cholecystokinin Tetrapeptide in Panic Disorder: Clinical and Behavioral Findings
Bradwejn et al.
Arch Gen Psychiatry 1991;48:603-610.
ABSTRACT