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Markus J. P. Kruesi, MD; Judith L. Rapoport, MD; Susan Hamburger, MS; Euthymia Hibbs, PhD; William Z. Potter, MD, PhD; Marge Lenane, MSW; Gerald L. Brown, MD

Arch Gen Psychiatry. 1990;47(5):419-426.

Abstract
• Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid, a metabolite of serotonin, were measured in relation to aggression, impulsivity, and social functioning in 29 children and adolescents with disruptive behavior disorders. The cerebrospinal fluid 5-hydroxyindoleacetic acid level was low compared with that of age-, sex-, and race-matched patients with obsessive-compulsive disorder. Within the disruptive group, significant negative correlations with age-corrected 5-hydroxyindoleacetic acid level were seen for the child's report of aggression toward people and the expressed emotionality of the child toward his or her mother; other correlations of age-corrected 5-hydroxyindoleacetic acid level with measures of aggression were in the expected negative direction but did not reach statistical significance. Impulsivity per se and socioenvironmental factors were not significantly related to cerebrospinal fluid 5-hydroxyindoleacetic acid concentration.

Author Affiliations
From the Child Psychiatry Branch (Drs Kruesi, Rapoport, and Hibbs and Mss Hamburger and Lenane), the Section of Clinical Pharmacology, Laboratory of Clinical Science (Dr Potter), and the Laboratory of Developmental Psychology (Dr Brown), National Institute of Mental Health, Bethesda, Md. Dr Brown is now with the National Institute of Alcohol Abuse and Alcoholism Division of Intramural and Clinical Biological Research, Bethesda, Md.

Footnotes
Accepted for publication September 11, 1989.

Reprint requests to National Institute of Mental Health, Child Psychiatry Branch, Bldg 10, Room 6N240, 9000 Rockville Pike, Bethesda, MD 20892 (Dr Kruesi).

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