You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 47 No. 6, June 1990 TABLE OF CONTENTS
  Archives
  •  Online Features
  ORIGINAL ARTICLES
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Naloxone-Reversible Analgesic Response to Combat-Related Stimuli in Posttraumatic Stress Disorder

A Pilot Study

Roger K. Pitman, MD; Bessel A. van der Kolk, MD; Scott P. Orr, PhD; Mark S. Greenberg, PhD

Arch Gen Psychiatry. 1990;47(6):541-544.


Abstract

• We tested the hypothesis that exposure to a stimulus resembling the original traumatic event would induce naloxone-reversible analgesia in patients with posttraumatic stress disorder (PTSD). Eight medication-free Vietnam veterans with PTSD and eight veterans without PTSD, matched for age and combat severity, viewed a 15-minute videotape of dramatized combat under naloxone hydrochloride and placebo conditions in a randomized double-blind crossover design. In the placebo condition, the subjects with PTSD showed a 30% decrease in reported pain intensity ratings of standardized heat stimuli after the combat videotape. No decrease in pain ratings occurred in the subjects with PTSD in the naloxone condition. The subjects without PTSD did not show a decrease in pain ratings in either condition. The results are consistent with the induction of opioid-mediated stress-induced analgesia in the patients with PTSD.



Author Affiliations

From the Manchester (NH) Veterans Affairs Medical Center (Drs Pitman and Orr), the Massachusetts Mental Health Center (Drs van der Kolk and Greenberg), and the Department of Psychiatry, Harvard Medical School, Boston, Mass (Drs Pitman, van der Kolk, Orr and Greenberg). Presented at the 141st Annual Meeting of the American Psychiatric Association, Montreal, Canada, May 9, 1988.


Footnotes

Accepted for publication October 13, 1989.

Reprint requests to Veterans Affairs Research Service, 228 Maple St, Manchester, NH 03103 (Dr Pitman).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Blockade of Endogenous Opioid Neurotransmission Enhances Acquisition of Conditioned Fear in Humans
Eippert et al.
J. Neurosci. 2008;28:5465-5472.
ABSTRACT | FULL TEXT  

Altered Pain Processing in Veterans With Posttraumatic Stress Disorder
Geuze et al.
Arch Gen Psychiatry 2007;64:76-85.
ABSTRACT | FULL TEXT  

Pain medication use among patients with posttraumatic stress disorder.
Schwartz et al.
Psychosomatics 2006;47:136-142.
ABSTRACT | FULL TEXT  

Brain Systems Underlying Susceptibility to Helplessness and Depression
Shumake and Gonzalez-Lima
Behav Cogn Neurosci Rev 2003;2:198-221.
ABSTRACT  

{micro}-Opioid receptors and limbic responses to aversive emotional stimuli
Liberzon et al.
Proc. Natl. Acad. Sci. USA 2002;99:7084-7089.
ABSTRACT | FULL TEXT  

Treating Traumatized Children: Clinical Implications of the Psychobiology of Posttraumatic Stress Disorder
COHEN et al.
Trauma Violence Abuse 2002;3:91-108.
ABSTRACT  

Pain and Emotion: Effects of Affective Picture Modulation
Meagher et al.
Psychosom. Med. 2001;63:79-90.
ABSTRACT | FULL TEXT  

Psychobiologic Mechanisms of Posttraumatic Stress Disorder
Charney et al.
Arch Gen Psychiatry 1993;50:294-305.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1990 American Medical Association. All Rights Reserved.