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Larry J. Siever, MD; Jeremy M. Silverman, PhD; Thomas B. Horvath, MD; Howard Klar, MD; Emil Coccaro, MD; Richard S. E. Keefe; Lynne Pinkham, MA; Paul Rinaldi, MA; Richard C. Mohs, PhD; Kenneth L. Davis, MD

Arch Gen Psychiatry. 1990;47(7):634-640.

Abstract
• To evaluate whether probands from a clinical sample diagnosed as having DSM-III schizotypal and/or paranoid personality disorder have a familial relationship to the schizophrenia-related disorders, the morbid risk for schizophrenia-related disorders and other psychiatric disorders were evaluated in the first-degree relatives of patients with schizotypal and/or paranoid personality disorder and compared with the corresponding risk for these disorders in the first-degree relatives of patients with other non-schizophrenia-related personality disorders. The morbid risk for all schizophrenia-related disorders, and specifically for schizophrenia-related personality disorders, was significantly greater among the relatives of the probands with schizotypal and/or paranoid personality disorder than among the relatives of probands with other personality disorder. The morbid risk for other psychiatric disorders did not differ significantly between the first-degree relatives of the schizotypal/paranoid personality disorder and the other personality disorder control proband samples. These results suggest a specific familial association between schizophrenia-related disorders, particularly schizophrenia-related personality disorders, and clinically diagnosed schizotypal patients.

Author Affiliations
From the Psychiatry Service, Bronx (NY) Veterans Administration Medical Center (Drs Siever, Silverman, Horvath, Coccaro, Mohs, and Davis; Messrs Keefe and Rinaldi; and Ms Pinkham); and Mt Sinai School of Medicine, New York, NY (Drs Siever, Silverman, Horvath, Klar, Coccaro, Mohs, and Davis, and Mr Keefe).

Footnotes
Accepted for publication September 25, 1989.

Reprint requests to Psychiatry Service, 116a, Bronx Veterans Administration Medical Center, Bronx, NY 10458 (Dr Siever).

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