This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Patients Treated With Clomipramine

Chawki Benkelfat, MD; Thomas E. Nordahl, MD, PhD; William E. Semple, PhD; A. Catherine King; Dennis L. Murphy, MD; Robert M. Cohen, MD, PhD

Arch Gen Psychiatry. 1990;47(9):840-848.

Abstract
• In a recent study, we reported abnormal local cerebral glucose metabolic rates in the orbital frontal cortex of patients with obsessive-compulsive disorder. Eight patients with obsessivecompulsive disorder scanned previously were scanned again during treatment with the tricyclic antidepressant clomipramine hydrochloride. Comparisons of local cerebral glucose metabolic rates for both groups showed a relative decrease in regions of the orbital frontal cortex and the left caudate, and an increase in other areas of the basal ganglia, including the right anterior putamen. When comparing patients who responded well to clomipramine with those who were either poor or partial responders, we found significant decreases only in the left caudate of patients who responded well to the drug. The present study suggests that clomipramine-induced improvement in obsessive-compulsive symptoms is associated with a return of regional brain metabolism to a more normal level in regions of the orbital frontal cortex and the caudate nucleus.

Author Affiliations
From the Section on Clinical Neuropharmacology, Laboratory of Clinical Science (Drs Benkelfat and Murphy), and the Section on Clinical Brain Imaging, Laboratory of Cerebral Metabolism (Drs Nordahl, Semple, and Cohen and Ms King), National Institute of Mental Health, Bethesda, Md. Dr Benkelfat is now with the Department of Psychiatry, McGill University, Montreal, Quebec. Dr Nordahl is now with the Department of Psychiatry, University of California, Davis.

Footnotes
Accepted for publication April 7, 1990.

Reprint requests to Research and Training Building, Department of Psychiatry, McGill University, 1033 Pine Ave W, Montreal, Quebec, Canada H3A1A1 (Dr Benkelfat).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Altered Corticostriatal Functional Connectivity in Obsessive-compulsive Disorder
Harrison et al.
Arch Gen Psychiatry 2009;66:1189-1200.
ABSTRACT | FULL TEXT  

Functional and Biochemical Alterations of the Medial Frontal Cortex in Obsessive-Compulsive Disorder
Yucel et al.
Arch Gen Psychiatry 2007;64:946-955.
ABSTRACT | FULL TEXT  

Cerebral Glucose Metabolism in Obsessive-Compulsive Hoarding
Saxena et al.
Am. J. Psychiatry 2004;161:1038-1048.
ABSTRACT | FULL TEXT  

Differential Brain Metabolic Predictors of Response to Paroxetine in Obsessive-Compulsive Disorder Versus Major Depression
Saxena et al.
Am. J. Psychiatry 2003;160:522-532.
ABSTRACT | FULL TEXT  

Differential Cerebral Metabolic Changes With Paroxetine Treatment of Obsessive-Compulsive Disorder vs Major Depression
Saxena et al.
Arch Gen Psychiatry 2002;59:250-261.
ABSTRACT | FULL TEXT  

Informed Consent and Neuroanatomic Correlates of Intentionality and Voluntariness Among Psychiatric Patients
Grimes et al.
Psychiatr. Serv. 2000;51:1561-1567.
ABSTRACT | FULL TEXT  

Neuropsychological Function, Drug Abuse, and Violence: A Conceptual Framework
FISHBEIN
Criminal Justice and Behavior 2000;27:139-159.
ABSTRACT  

Orbitofrontal Cortex and Human Drug Abuse: Functional Imaging
London et al.
Cereb Cortex 2000;10:334-342.
ABSTRACT | FULL TEXT  

Orbital Frontal and Amygdala Volume Reductions in Obsessive-compulsive Disorder
Szeszko et al.
Arch Gen Psychiatry 1999;56:913-919.
ABSTRACT | FULL TEXT  

The Neuropsychiatry of Chronic Cocaine Abuse
Bolla et al.
J. Neuropsychiatry Clin. Neurosi. 1998;10:280-289.
ABSTRACT | FULL TEXT  

Higher Prevalence of Obsessive-Compulsive Symptoms in Patients With Blepharospasm Than in Patients With Hemifacial Spasm
Broocks et al.
Am. J. Psychiatry 1998;155:555-557.
ABSTRACT | FULL TEXT  

A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
Peterson et al.
Arch Gen Psychiatry 1998;55:326-333.
ABSTRACT | FULL TEXT  

Normal Caudate Nucleus in Obsessive-compulsive Disorder Assessed by Quantitative Neuroimaging
Aylward et al.
Arch Gen Psychiatry 1996;53:577-584.
ABSTRACT  

Functional Magnetic Resonance Imaging of Symptom Provocation in Obsessive-compulsive Disorder
Breiter et al.
Arch Gen Psychiatry 1996;53:595-606.
ABSTRACT  

The basal ganglia and adaptive motor control
Graybiel et al.
Science 1994;265:1826-1831.
ABSTRACT  

Retrocallosal White Matter Abnormalities in Patients With Obsessive-compulsive Disorder
Breiter et al.
Arch Gen Psychiatry 1994;51:663-664.
ABSTRACT  

A Multicenter Investigation of Fixed-Dose Fluoxetine in the Treatment of Obsessive-compulsive Disorder
Tollefson et al.
Arch Gen Psychiatry 1994;51:559-567.
ABSTRACT  

Regional Cerebral Blood Flow Measured During Symptom Provocation in Obsessive-Compulsive Disorder Using Oxygen 15--Labeled Carbon Dioxide and Positron Emission Tomography
Rauch et al.
Arch Gen Psychiatry 1994;51:62-70.
ABSTRACT  

Caudate Glucose Metabolic Rate Changes With Both Drug and Behavior Therapy for Obsessive-Compulsive Disorder
Baxter et al.
Arch Gen Psychiatry 1992;49:681-689.
ABSTRACT  

Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder: Revisualization During Pharmacotherapy
Swedo et al.
Arch Gen Psychiatry 1992;49:690-694.
ABSTRACT  

Toward a Neuroanatomy of Obsessive-Compulsive Disorder
Insel
Arch Gen Psychiatry 1992;49:739-744.
ABSTRACT  

Preliminary Data on the Metabolic Brain Pattern of Patients With Winter Seasonal Affective Disorder
Cohen et al.
Arch Gen Psychiatry 1992;49:545-552.
ABSTRACT  

The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications
Swerdlow et al.
J Psychopharmacol 1992;6:176-190.
ABSTRACT  

Regional Cerebral Glucose Metabolism of Women With Trichotillomania
Swedo et al.
Arch Gen Psychiatry 1991;48:828-833.
ABSTRACT