 |
|
Changes in Mood, Craving, and Sleep During Short-term Abstinence Reported by Male Cocaine AddictsA Controlled, Residential Study
William W. Weddington, MD;
Barry S. Brown, PhD;
Charles A. Haertzen, PhD;
Edward J. Cone, PhD;
Elizabeth M. Dax, MD, PhD;
Ronald I. Herning, PhD;
Barry S. Michaelson, MA
Arch Gen Psychiatry. 1990;47(9):861-868.
Abstract
| |
• We examined changes over 28 days in mood states, craving for cocaine, and sleep during short-term abstinence reported by 12 male, predominantly intravenous-using, cocaine-addicted subjects residing in a research facility. For comparison, we examined 10 nonaddicted control subjects. There were no significant differences between cocaine addicts and controls regarding demographics and selected DSM-III-R diagnoses other than psychoactive substance use disorder and antisocial personality disorder. There were significantly higher scores of psychiatric symptoms reported by cocaine addicts 1 week before admission. Mood-distress and depression scores recorded at admission and during short-term abstinence were significantly greater than those reported by controls. Addicts' mood-distress scores and craving for cocaine were greatest at admission and decreased gradually and steadily during the 28-day study. There were no significant differences between groups regarding reports of sleep other than difficulty falling asleep and clearheadedness on arising. Although there were significant differences in resting heart rate at admission and over time, there were no significant differences in weight gain or blood pressure. Given the absence of a classic "withdrawal" pattern, "short-term abstinence" may be a more appropriate classification of psychological and physical phenomena experienced by cocaine addicts who initiate abstinence in a controlled environment.
Author Affiliations
From the National Institute on Drug Abuse, Rockville, Md (Drs Weddington and Brown), and the Addiction Research Center of the National Institute on Drug Abuse, Baltimore, Md (Drs Haertzen, Cone, Dax, and Herning and Mr Michaelson). Dr Weddington is currently with the Department of Psychiatry, University of Illinois at Chicago.
Footnotes
Accepted for publication December 7, 1989.
The opinions expressed herein are those of the authors and do not necessarily reflect the official position of the National Institute on Drug Abuse or any other part of the US Department of Health and Human Services.
Reprint requests to Department of Psychiatry, University of Illinois at Chicago, 912 S Wood St, Chicago, IL 60612 (Dr Weddington).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Treatment of Depression in Patients With Alcohol or Other Drug Dependence: A Meta-analysis
Nunes and Levin
JAMA 2004;291:1887-1896.
ABSTRACT
| FULL TEXT
Amantadine in the Treatment of Cocaine-Dependent Patients With Severe Withdrawal Symptoms
Kampman et al.
Am. J. Psychiatry 2000;157:2052-2054.
ABSTRACT
| FULL TEXT
Health Services Research Among Crack-Cocaine Users: A Case Study From the Midwest
SIEGAL et al.
American Behavioral Scientist 1998;41:1063-1078.
ABSTRACT
Management of Cocaine Abuse and Dependence
Mendelson and Mello
NEJM 1996;334:965-972.
FULL TEXT
Noradrenergic Dysregulation During Discontinuation of Cocaine Use in Addicts
McDougle et al.
Arch Gen Psychiatry 1994;51:713-719.
ABSTRACT
New Pharmacotherapies for Cocaine Dependence... Revisited
Meyer
Arch Gen Psychiatry 1992;49:900-904.
ABSTRACT
Drugs for Cocaine Dependence: Not Easy-Reply
Margolin et al.
Arch Gen Psychiatry 1992;49:905-906.
ABSTRACT
Cocaine addiction: psychology and neurophysiology
Gawin
Science 1991;251:1580-1586.
ABSTRACT
|
