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V. Replication of Psychiatric Status

Salvatore Mannuzza, PhD; Rachel G. Klein, PhD; Noreen Bonagura, MSW; Patricia Malloy; Tina L. Giampino; Kathy A. Addalli

Arch Gen Psychiatry. 1991;48(1):77-83.

Abstract
• We previously reported a prospective follow-up study of 101 young adult males whose conditions had been diagnosed as hyperactivity in childhood. Compared with controls, probands had significantly higher rates of attention-deficit, antisocial, and drug use disorders at follow-up (mean age, 18 years). The present study was an attempt to replicate these findings on an independent sample of 94 hyperactive boys who were seen at the same clinic, compared with 78 normal controls. Assessments were made by clinicians who were blind to group membership. Information was obtained for 90% of the original cohort. As in the previous study, significantly more probands than controls were given ongoing diagnoses of attention-deficit disorder (43% vs 4%), antisocial disorders (32% vs 8%), and drug use disorders (10% vs 1%). Furthermore, the absolute rates of these disorders were comparable for corresponding groups across studies, and the adjusted odds ratios did not differ significantly. As previously, there was no increased risk for affective disorders in the grown hyperactive children. The present study provides a powerful replication of the nature of the young adult outcome of childhood hyperactivity.

Author Affiliations
From the Children's Behavior Disorders Clinic, Hillside Division, Research Department, Long Island Jewish Medical Center, New Hyde Park, NY (Drs Mannuzza and Klein and Mss Bonagura, Malloy, Giampino, and Addalli), the Department of Clinical Psychology, New York (NY) State Psychiatric Institute (Drs Mannuzza and Klein and Mss Giampino and Addalli), and Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY (Drs Mannuzza and Klein).

Footnotes
Accepted for publication April 20, 1990.

Presented in part at the Annual Meeting of the American Psychiatric Association, San Francisco, Calif, May 11, 1989.

Reprint requests to Department of Clinical Psychology, New York State Psychiatric Institute, 722 W 168th St, New York, NY 10032 (Dr Mannuzza).

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