Auditory P300 and Eye Tracking Dysfunction in Schizophrenic Pedigrees

doi:10.1001/archpsyc.1991.01810340031004

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Vol. 48 No. 10, October 1991

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Auditory P300 and Eye Tracking Dysfunction in Schizophrenic Pedigrees

Douglas H. R. Blackwood, MRCPsych; David M. St Clair, MRCPsych; Walter J. Muir, MRCPsych; John C. Duffy, MSc

Arch Gen Psychiatry. 1991;48(10):899-909.

Abstract

• Several psychophysiological abnormalities associatedwith schizophrenia have been proposed as genetic trait markersof vulnerability to the disorder. Smooth pursuit eye trackingdysfunction and abnormal long latency eventrelated potentialsare the most promising candidates. Both are independent of theeffects of psychotropic medication or mental state at the timeof testing, and twin studies demonstrate that each has a highlevel of heritability. Having recorded smooth pursuit eye trackingand event-related potentials in 20 high-density schizophrenicfamilies, we find abnormalities in one or both measures in mostof the families studied. The abnormalities, when present, occurin the family members with schizophrenia and other forms offunctional psychosis, and they have a bimodal distribution withapproximately half the nonschizophrenic relatives also showingeye tracking dysfunction and/or abnormal eventrelated potentials.Some of these relatives had psychiatric symptoms; others werenormal. Our results suggest that psychophysiological examinationcan help to clarify the boundaries of schizophrenia spectrumdisorder. By helping to decide the phenotypic status of nonschizophrenicfamily members, this should increase the power of DNA linkagestudies.

Author Affiliations

From the University Department of Psychiatry, Royal Edinburgh Hospital, and the Medical Research Council Human Genetics Unit, Western General Hospital (Drs Blackwood, St Clair, and Muir), and the University Department of Statistics (Mr Duffy), Edinburgh, Scotland.

Footnotes

Accepted for publication September 12, 1990.

Reprint requests to Department of Psychiatry, The Kennedy Tower,Royal Edinburgh Hospital, Morningside Park, Edinburgh, ScotlandEH10 5HF (Dr Blackwood).

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