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Joyce G. Small, MD; Marietta H. Klapper, MS; Victor Milstein, PhD; Jeffrey J. Kellams, MD; Marvin J. Miller, MD; Jon D. Marhenke, MD; Iver F. Small, MD

Arch Gen Psychiatry. 1991;48(10):915-921.

Abstract
• Fifty-two hospitalized manic patients were randomized to treatment with either carbamazepine or lithium carbonate after a 2-week drug withdrawal period. All of the probands were tertiary referrals with a high proportion of failures of previous lithium and other treatment. Weekly ratings of manic, depressive, and psychotic symptoms were obtained for 8 weeks, and responders were followed up for up to 2 years. One third of patients responded favorably. Double-blind assessments revealed no statistically reliable differences between the two treatment groups. Patients receiving carbamazepine were somewhat more manageable than patients treated with lithium early in the study, whereas lithium-treated patients remained longer in the follow-up phase. However, numbers of long-term survivors were too small to be conclusive. This study adds to the growing body of evidence that acutely manic patients respond as well to carbamazepine as to lithium. However, monotherapy with either drug is not sufficient for the majority of manic patients who are referred for tertiary care.

Author Affiliations
From the Department of Psychiatry, Indiana University School of Medicine and Larue D. Carter Memorial Hospital, Indianapolis.

Footnotes
Accepted for publication March 26, 1991.

Reprints not available.

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References
APPI Online CME 2007;2007:2-2.
FULL TEXT  

What Is a "Mood Stabilizer"? An Evidence-Based Response
Bauer and Mitchner
Am. J. Psychiatry 2004;161:3-18.
ABSTRACT | FULL TEXT  

Practice Guideline for the Treatment of Patients With Bipolar Disorder (Revision)
Hirschfeld et al.
Focus 2003;1:64-110.
FULL TEXT  

Psychopharmacological Treatment of Bipolar Disorder
Walsh
Research on Social Work Practice 1998;8:406-425.
ABSTRACT  

Treatment of Inhalant-Induced Psychotic Disorder With Carbamazepine Versus Haloperidol
Hernandez-Avila et al.
Psychiatr. Serv. 1998;49:812-815.
ABSTRACT | FULL TEXT  

Current Therapeutic Profile of Lithium
Gershon and Soares
Arch Gen Psychiatry 1997;54:16-20.
ABSTRACT  

Unanswered Questions, Unknown Future for One of Our Oldest Medications
Gitlin and Altshuler
Arch Gen Psychiatry 1997;54:21-23.
ABSTRACT  

The Use of Anticonvulsants in Psychiatry
Gaulin
Journal of Pharmacy Practice 1996;9:104-112.
ABSTRACT  

Lithium in the Treatment of Mood Disorders
Price and Heninger
NEJM 1994;331:591-598.
FULL TEXT  

Efficacy of Divalproex vs Lithium and Placebo in the Treatment of Mania
Bowden et al.
JAMA 1994;271:918-924.
ABSTRACT  

Progress in Psychiatry- Second of Two Parts
Michels and Marzuk
NEJM 1993;329:628-638.
FULL TEXT