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A Double-blind Desipramine Substitution During Long-term Clomipramine Treatment in Children and Adolescents With Obsessive-Compulsive Disorder
Henrietta L. Leonard, MD;
Susan E. Swedo, MD;
Marge C. Lenane, MSW;
David C. Rettew;
Deborah L. Cheslow, MA;
Susan D. Hamburger, MS;
Judith L. Rapoport, MD
Arch Gen Psychiatry. 1991;48(10):922-927.
Abstract
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• Twenty-six chilndren and adolescents with severe primary obsessive-compulsive disorder receiving long-term clomipramine hydrochloride maintenance treatment (mean±SD, 17.1±8.3 months; range, 4 to 32 months) entered an 8-month double-blind desipramine hydrochloride substitution study to assess the necessity of continued drug treatment. All patients received clomipramine for the first 3 months, then half continued with clomipramine therapy (nonsubstituted group) and half had desipramine blindly substituted for the next 2 months; all subjects again received clomipramine for the last 3 study months. Eight (89%) of nine of the substituted and only two (18%) of 11 of the nonsubstituted group subjects relapsed during the 2-month comparison period. Long-term clomipramine treatment seems necessary for this population of children and adolescents with obsessive-compulsive disorder. However, even patients receiving maintenance clomipramine treatment throughout the entire study had continued obsessivecompulsive symptoms, which varied in severity over time.
Author Affiliations
From the National Institute of Mental Health, Child Psychiatry Branch, Bethesda, Md.
Footnotes
Accpted for publication March 27, 1991.
Reprint requests to Child Psychiatry Branch, National Institute of Mental Health, Bldg 10, Room 6N240,9000 Rockville Pike, Bethesda, MD 20892 (Dr Leonard).
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