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Recruitment and Screening of Normal Controls

Derri L. Shtasel, MD; Raquel E. Gur, MD, PhD; P. David Mozley, MD; Jeffrey Richards; Margaret M. Taleff, MS; Carolyn Heimberg, MD; Fiona Gallacher; Ruben C. Gur, PhD

Arch Gen Psychiatry. 1991;48(11):1022-1025.

Abstract
• We examined the process of accruing healthy control subjects for biomedical research on brain function. Of 1670 responders to newspaper advertising, 23.1% were uninterested when learning more about the studies, and 50.9% of those remaining were found by structured telephone screening to meet exclusionary criteria for having a history of psychiatric, neurologic, or medical disease that might affect brain function. Of 312 volunteers passing the telephone screening who came to an in-person evaluation by a physician and agreed to participate, 49.7% were found to meet exclusionary criteria, and only 157 were admitted to the study. This underscores the importance of attending to the issue of screening and assessment of "normal volunteers." Alternative strategies should be considered for enriching the pool.

Author Affiliations
From the Mental Health Clinical Research Center on Schizophrenia, Section of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia.

Footnotes
Accepted for publication March 21, 1991.

Reprint requests to Department of Psychiatry, 205 Piersol Bldg, Hospital of the University of Pennsylvania, Philadelphia, PA 19104-4283 (Dr Shtasel).

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