Lack of linkage to chromosome 5q11-q13 markers in six schizophrenia pedigrees

R. R. Crowe, D. W. Black, R. Wesner, N. C. Andreasen, A. Cookman and J. Roby
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.

We examined linkage between schizophrenia and five genetic markers on chromosome 5 in six pedigrees. Analyses were run considering the affected phenotype to be schizophrenia, schizophrenia plus a spectrum of related disorders, and these disorders plus any axis I diagnosis. None of the analyses were suggestive of linkage at any of the markers, either considering the pedigrees individually or in the aggregate. In our pedigrees, multipoint linkage analyses excluded much of the region that had supported linkage in an earlier study. These findings are consistent with other attempts to replicate the chromosome 5 linkage finding.