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I. Volumetric Analysis of Brain and Cerebrospinal Fluid

Raquel E. Gur, MD, PhD; P. David Mozley, MD; Susan M. Resnick, PhD; Derri Shtasel, MD; Mark Kohn, MD; Robert Zimmerman, MD; Gabor Herman, PhD; Scott Atlas, MD; Robert Grossman, MD; Roland Erwin, PhD; Ruben C. Gur, PhD

Arch Gen Psychiatry. 1991;48(5):407-412.

Abstract
• The study reports magnetic resonance imaging data for 42 patients with schizophrenia and 43 normal controls. Volumetric measures were obtained with a validated computerized algorithm for segmentation of cranial volume into brain tissue and central and peripheral cerebrospinal fluid (CSF), with high interoperator reliability. Patients did not differ significantly in wholebrain volume, but had higher whole-brain CSF volume and higher ratios of ventricular and sulcal CSF to cranial volume. Covarying age and education did not affect the differences. However, there was considerable overlap both in CSF volumes and in volumecranium ratios, and most patients were within the normal range. This suggests that anatomic changes reflected in CSF can provide a limited substrate for schizophrenia and may apply only to subpopulations. Although there was no gender x diagnosis interaction, the results for sulcal CSF were significant only for men, whereas for women, the ventricular ratios were marginally higher in patients.

Author Affiliations
From the Department of Psychiatry (Drs R. E. Gur, Mozley, Resnick, Shtasel, Erwin, and R. C. Gur) and Radiology (Drs Kohn, Zimmerman, Herman, Atlas, and Grossman), University of Pennsylvania, Philadelphia.

Footnotes
Accepted for publication October 15, 1990.

Reprint requests to Department of Psychiatry, Neuropsychiatry Section, 205 Piersol Bldg, University of Pennsylvania, Philadelphia, PA 19104 (Dr R. E. Gur).

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