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Personality and Cerebrospinal Fluid Monoamine Metabolites in Alcoholics and Controls
Rhona Limson, MD;
David Goldman, MD;
Alec Roy, MB;
Danuta Lamparski, PhD;
Bernard Ravitz, MD;
Bryon Adinoff, MD;
Markku Linnoila, MD, PhD
Arch Gen Psychiatry. 1991;48(5):437-441.
Abstract
• Alcoholics as a group have been consistently reported to show differences from controls on various personality-inventories. Moreover, neurobiologic substrates have been postulated to underlie personality dimensions. Therefore, we compared alcoholics with controls on measures of personality and investigated relationships between measures of personality and cerebrospinal fluid monoamine metabolite concentrations. The alcoholics were significantly different from controls on many personality measurements. There were significant, negative correlations between interview-derived lifetime aggression scores and cerebrospinal fluid concentrations of both the serotonin metabolite 5-hydroxyindoleacetic acid and the dopamine metabolite homovanillic acid. However, there were no significant correlations between any cerebrospinal fluid monoamine metabolite concentrations and scores on personality inventories.
Author Affiliations
From the Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md.
Footnotes
Accepted for publication May 2, 1990.
Reprint requests to Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bldg 10, Room 3B19, 9000 Rockville Pike, Bethesda, MD 20892 (Dr Linnoila).
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