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Katherine A. Halmi, MD; Elke Eckert, MD; Peggy Marchi, PhD; Vincent Sampugnaro, MA; Robin Apple, MA; Jacob Cohen, PhD

Arch Gen Psychiatry. 1991;48(8):712-718.

Abstract
• The comorbidity of psychiatric diagnoses was examined with the Diagnostic Interview Schedule in 62 women who participated in a 10-year follow-up study of anorexia nervosa. Sixty-two age- and sex-matched controls, their parents, and parents of the anorectic probands were also interviewed with the Diagnostic Interview Schedule. There was a statistically significant comorbidity of the affective and anxiety disorders with anorexia nervosa. The first-degree relatives of the anorectic probands had significantly more alcoholism and total number of psychiatric diagnoses compared with the first-degree relatives of controls. There were two mothers with bulimia nervosa, two cases of anorexia nervosa and two of bulimia nervosa in other first-degree relatives of anorectic probands, and no cases of eating disorders in the first-degree relatives of controls.

Author Affiliations
From the Department of Psychiatry, Cornell University Medical College, White Plains, NY (Drs Halmi and Marchi, and Mr Sampugnaro); Department of Psychiatry, University of Minnesota, Minneapolis (Dr Eckert and Ms Apple); and Department of Psychology, New York (NY) University (Dr Cohen).

Footnotes
Accepted for publication December 10, 1990.

Reprint requests to Eating Disorder Program, Cornell Medical Center-Westchester Division, 21 Bloomingdale Rd, White Plains, NY 10605 (Dr Halmi).

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