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Richard Abrams, MD; Conrad M. Swartz, PhD, MD; Chandragupta Vedak, MD

Arch Gen Psychiatry. 1991;48(8):746-748.

Abstract
• In a random-assignment, double-blind, controlled comparison in 38 melancholic men, overall antidepressant potency of high-dose electroconvulsive therapy (378-mC charge) given with right unilateral electrode placement was not significantly different from that with bilateral placement, although there was a trend for faster improvement with bilateral ECT. The suprathreshold character of the stimulus, about 2.5 times the expected seizure threshold, may have contributed to the high efficacy of brief-pulse right unilateral electroconvulsive therapy found in this study.

Author Affiliations
From the Departments of Psychiatry and Behavioral Sciences (Drs Abrams, Swartz, and Vedak), Psychology (Dr Abrams), and Pharmacology (Dr Swartz), University of Health Sciences/Chicago Medical School, North Chicago (III), and North Chicago Veterans Affairs Medical Center (Drs Abrams, Swartz, and Vedak).

Footnotes
Accepted for publication September 10, 1990.

Reprint requests to Department of Psychiatry and Behavioral Sciences, University of Health Sciences/Chicago Medical School, 3333 Green Bay Rd, North Chicago, IL 60064 (Dr Abrams).

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