This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Preliminary Studies

Monte S. Buchsbaum, MD; J. Patrick Kesslak, PhD; Gary Lynch, PhD; Helena Chui, MD; Joseph Wu, MD; Nancy Sicotte; Erin Hazlett; Evelyn Teng, PhD; Carl W. Cotman, PhD

Arch Gen Psychiatry. 1991;48(9):840-847.

Abstract
• Positron emission tomography with fludeoxyglucose F 18 was used to assess cortical metabolic rate during an olfactory memory task in six patients with dementia of the Alzheimer type. Metabolic activity was compared with that of both agematched controls performing the olfactory task and controls resting with their eyes closed. Patients had lower metabolic rates in the anterior portion of the medial-temporal cortex than did controls, and the difference was greatest between patients and the controls performing the memory task. This region is known to receive a large olfactory input and has been implicated in the encoding of human memory. Normal controls resting with their eyes closed had significantly lower metabolic rates in this area when compared with normal controls performing the task. Our results are consistent with those of earlier reports of temporal lobe decreases in metabolic rate and extend them through the examination of areas salient to the behavioral loss.

Author Affiliations
From the Brain Imaging Center, University of California, Irvine (Drs Buchsbaum, Kesslak, Lynch, Wu, and Cotman and Ms Sicotte), and from the University of Southern California, Los Angeles (Drs Chui and Teng and Ms Hazlett).

Footnotes
Accepted for publication February 14, 1991.

Reprint requests to the Brain Imaging Center, Room 164, Whitby Research Building, University of California, Irvine, Irvine, CA 92717 (Dr Buchsbaum).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The relationship between cerebral Alzheimer's disease pathology and odour identification in old age
Wilson et al.
J. Neurol. Neurosurg. Psychiatry 2007;78:30-35.
ABSTRACT | FULL TEXT  

Olfactory Function in Mild Cognitive Impairment and Alzheimer's Disease: An Investigation Using Psychophysical and Electrophysiological Techniques
Peters et al.
Am. J. Psychiatry 2003;160:1995-2002.
ABSTRACT | FULL TEXT  

Rating of Different Olfactory Judgements in Alzheimer's Disease
Royet et al.
Chem Senses 2001;26:409-417.
ABSTRACT | FULL TEXT  

Hippocampal, but not amygdala, activity at encoding correlates with long-term, free recall of nonemotional information
Alkire et al.
Proc. Natl. Acad. Sci. USA 1998;95:14506-14510.
ABSTRACT | FULL TEXT  

Olfaction in Neurodegenerative Disease: A Meta-analysis of Olfactory Functioning in Alzheimer's and Parkinson's Diseases
Mesholam et al.
Arch Neurol 1998;55:84-90.
ABSTRACT | FULL TEXT