 |
|
Cerebrospinal Fluid Neurochemistry in Children and Adolescents With Obsessive-Compulsive Disorder
Susan E. Swedo, MD;
Henrietta L. Leonard, MD;
Markus J. P. Kruesi, MD;
David C. Rettew;
Samuel J. Listwak;
Wade Berrettini, MD;
Mark Stipetic;
Susan Hamburger;
Phillip W. Gold, MD;
William Z. Potter, MD, PhD;
Judith L. Rapoport, MD
Arch Gen Psychiatry. 1992;49(1):29-36.
Abstract
| |
• Cerebrospinal fluid hormones, monoaminergic metabolites, and dynorphin A (1-8 sequence) were examined in 43 children with severe, primary obsessive-compulsive disorder. Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid were positively correlated with one of eight obsessivecompulsive disorder severity ratings and three of seven measures of improvement following 5 weeks of treatment with clomipramine hydrochloride. Arginine vasopressin concentration was significantly and negatively correlated with several ratings of obsessive-compulsive disorder symptom severity, while oxytocin concentration was positively correlated with depressive symptoms. The ratio of arginine vasopressin to oxytocin was also negatively correlated with obsessive-compulsive disorder and depressive symptoms. Comorbid affective disorder was associated with decreased arginine vasopressin concentrations, while concomitant anxiety disorder was associated with increased oxytocin. Dynorphin A (1-8 sequence), homovanillic acid, corticotropin, 3-methoxy-4-hydroxyphenylglycol, and corticotropin releasing hormone were not significantly related to obsessive-compulsive disorder symptoms. These results seem to indicate that arginine vasopressin may be related to obsessive-compulsive disorder symptom severity, while 5-hydroxyindoleacetic acid might be associated with drug response.
Author Affiliations
From the Child Psychiatry Branch (Drs Swedo, Leonard, Kruesi, and Rapoport, Mr Rettew, and Ms Hamburger), the Biological Psychiatry Branch (Mr Listwak and Dr Gold), the Clinical Neurogenics Branch (Dr Berrettini), and the Section on Clinical Pharmacology, Laboratory of Clinical Science (Mr Stipetic and Dr Potter), National Institute of Mental Health, Bethesda, Md.
Footnotes
Accepted for publication May 17, 1991.
Reprint requests to the Child Psychiatry Branch, National Institute of Mental Health, Bldg 10, Room 6N240, 9000 Rockville Pike, Bethesda, MD 20892 (Dr Swedo).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Enhanced Dopamine Transporter Density in Psychotropic-Naive Patients With Obsessive-Compulsive Disorder Shown by [123I]{beta}-CIT SPECT
van der Wee et al.
Am. J. Psychiatry 2004;161:2201-2206.
ABSTRACT
| FULL TEXT
Increased Medial Thalamic Choline in Pediatric Obsessive-Compulsive Disorder as Detected by Quantitative in Vivo Spectroscopic Imaging
Rosenberg et al.
J Child Neurol 2001;16:636-641.
ABSTRACT
Psychopathology and personality characteristics in relation to blood serotonin in Tourette's syndrome and obsessive-compulsive disorder
Cath et al.
J Psychopharmacol 2001;15:111-119.
ABSTRACT
CENTRAL NERVOUS SYSTEM SEROTONIN AND PERSONALITY AS VARIABLES CONTRIBUTING TO EXCESSIVE ALCOHOL CONSUMPTION IN NON-HUMAN PRIMATES
Higley and Bennett
Alcohol Alcohol 1999;34:402-418.
ABSTRACT
| FULL TEXT
Cerebrospinal Fluid Vasopressin Levels: Correlates With Aggression and Serotonin Function in Personality-Disordered Subjects
Coccaro et al.
Arch Gen Psychiatry 1998;55:708-714.
ABSTRACT
| FULL TEXT
Elevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls
Leckman et al.
Arch Gen Psychiatry 1994;51:782-792.
ABSTRACT
Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine
Altemus et al.
Arch Gen Psychiatry 1994;51:794-803.
ABSTRACT
A 2- to 7-Year Follow-up Study of 54 Obsessive-Compulsive Children and Adolescents
Leonard et al.
Arch Gen Psychiatry 1993;50:429-439.
ABSTRACT
Psychiatry
Freedman and Stahl
JAMA 1992;268:403-405.
ABSTRACT
|
