Abnormalities in the Regulation of Vasopressin and Corticotropin Releasing Factor Secretion in Obsessive-Compulsive Disorder

doi:10.1001/archpsyc.1992.01820010009002

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Vol. 49 No. 1, January 1992

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Abnormalities in the Regulation of Vasopressin and Corticotropin Releasing Factor Secretion in Obsessive-Compulsive Disorder

Margaret Altemus, MD; Teresa Pigott, MD; Konstantine T. Kalogeras, MD; Mark Demitrack, MD; Billinda Dubbert, MSN; Dennis L. Murphy, MD; Philip W. Gold, MD

Arch Gen Psychiatry. 1992;49(1):9-20.

Abstract

• In light of prior data that the central administrationof vasopressin in animals is associated with abnormal persistenceof behaviors acquired under aversive conditioning, we studiedthe secretion of arginine vasopressin into the cerebrospinalfluid and plasma in patients with obsessivecompulsive disorderand controls. Patients with obsessivecompulsive disorder hadsignificantly elevated basal levels of arginine vasopressinin the cerebrospinal fluid and significantly increased secretionof arginine vasopressin into the plasma in response to hypertonicsaline administration. Moreover, seven of 12 patients with obsessivecompulsivedisorder showed a loss of the normal linear relationship betweenplasma arginine vasopressin level and osmolality. In addition,cerebrospinal fluid corticotropin releasing hormone, which hassynergistic effects with arginine vasopressin centrally andat the pituitary gland, was also significantly elevated in patientswith obsessivecompulsive disorder compared with controls.

Author Affiliations

From the Clinical Neuroendocrinology Branch (Drs Altemus, Kalogeras, and Gold and Ms Dubbert) and the Laboratory of Clinical Science (Drs Pigott and Murphy), National Institute of Mental Health, Bethesda, Md, and the Department of Psychiatry, University of Michigan Medical Center, Ann Arbor (Dr Demitrack).

Footnotes

Accepted for publication June 27, 1991.

Reprint requests to Bldg 10, Room 3S231, 9000 Rockville Pike,Bethesda, MD 20892 (Dr Altemus).

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