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Jim Mintz, PhD; Lois Imber Mintz, PhD; Mary Jane Arruda, MS; Sun Sook Hwang, MS

Arch Gen Psychiatry. 1992;49(10):761-768.

Abstract
• This study evaluated the effects of antidepressants and psychotherapy on work impairment in depressed patients. Original databases from 10 published treatment studies were compiled and analyzed (N=827). Functional work impairment was common at baseline, manifested by unemployment (11 %) or on-the-job performance problems (absenteeism, decreased productivity, interpersonal problems, 44%). Generally, work outcomes were good when treatment was symptomatically effective, but the trajectories of work restoration and symptom remission were different, with work recovery appearing to take considerably longer. Relapse was an important determinant of long-term occupational outcome, particularly for seriously ill patients for whom relapse meant rehospitalization or other profound social disruption. Affective impairment was distinguished from functional impairment, with the former characterizing milder depression and the latter characterizing moderate to severe depression. Some methodological recommendations are discussed.

Author Affiliations
From the Department of Psychiatry and Biobehavioral Sciences, School of Medicine, UCLA (Drs J. Mintz and L. I. Mintz and Mss Arruda and Hwang), and West Los Angeles Veterans Affairs Medical Center (Dr J. Mintz), Los Angeles, Calif.

Footnotes
Accepted for publication March 5, 1992.

Reprint requests to West Los Angeles Veterans Affairs Medical Center (691/B117), 11301 Wilshire Blvd, Los Angeles, CA 90073 (Dr J. Mintz).

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